Question 1

What routes can Irinotecan be administered by?

Accepted Answer

Available routes: IV.

Question 2

Is Irinotecan a controlled substance?

Accepted Answer

Irinotecan is not federally scheduled in the US. Controlled-drug status differs by country — verify your local rules.

Question 3

What are the warnings or contraindications for Irinotecan?

Accepted Answer

Early and late diarrhea syndromes. Early: cholinergic (treat with atropine). Late: secretory (potentially fatal). Myelosuppression. Atropine pretreatment recommended in dogs.

Question 4

What are the side effects of Irinotecan?

Accepted Answer

Reported side effects, adverse reactions, and contraindications for Irinotecan: Early and late diarrhea syndromes. Early: cholinergic (treat with atropine). Late: secretory (potentially fatal). Myelosuppression. Atropine pretreatment recommended in dogs.

Question 5

How does Irinotecan work?

Accepted Answer

Prodrug converted by carboxylesterases to active metabolite SN-38, which inhibits topoisomerase I. SN-38 is 100-1000x more potent than parent compound.

Irinotecan

Drug Class

Routes

Mechanism of Action

Side effects & warnings

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