ExoticRx · exoticrx.com/drugs/lapatinib
US brand names:Tykerb
Lapatinib is dosed at 10–25 mg/kg PO q24h in dogs, per Papich Handbook of Veterinary Drugs, 5th Ed. Verify against current literature before clinical use.
Dual tyrosine kinase inhibitor of EGFR (ErbB1) and HER2 (ErbB2). Blocks downstream MAPK and PI3K/Akt signaling. Investigational in canine mammary carcinoma.
Experimental in veterinary oncology. Hepatotoxicity, GI toxicity, and cardiac effects possible. Monitor liver enzymes. Limited veterinary data.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 10–25 mg/kg | q24h | Extrapolated | Papich Handbook of Veterinary Drugs, 5th Ed |
| Cat (Domestic) | PO | 10–25 mg/kg | q24h | Extrapolated | Papich Handbook of Veterinary Drugs, 5th Ed |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.