What is Lincomycin used for?

Lincomycin is indicated for: Gram-positive and anaerobic infections.

Which species have cited Lincomycin dosing data?

Lincomycin dosing in the ExoticRx formulary covers 1 species: Dog (Domestic).

Is Lincomycin a controlled substance?

Lincomycin is not federally scheduled in the US. Controlled-drug status differs by country — verify your local rules.

What are the warnings or contraindications for Lincomycin?

CONTRAINDICATED in rabbits, guinea pigs, hamsters (fatal dysbiosis). GI upset. Pseudomembranous colitis risk. Give on empty stomach.

What are the side effects of Lincomycin?

Reported side effects, adverse reactions, and contraindications for Lincomycin: CONTRAINDICATED in rabbits, guinea pigs, hamsters (fatal dysbiosis). GI upset. Pseudomembranous colitis risk. Give on empty stomach.

How does Lincomycin work?

Binds 50S ribosomal subunit, inhibiting bacterial protein synthesis. Activity against gram-positive and anaerobic bacteria.

Lincomycin

US brand names:Lincocin

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Contraindicated in Rabbit, Chinchilla, Hamster, Degu, Guinea Pig

Rabbit: Oral lincosamides cause fatal dysbiosis in rabbitsSame mechanism as oral beta-lactams — selective destruction of gram-positive hindgut flora. Never administer oral clindamycin or lincomycin to rabbits.
Chinchilla: Oral lincosamides cause fatal dysbiosis in chinchillasClindamycin and lincomycin destroy gram-positive hindgut flora and precipitate fatal Clostridium enterotoxemia in chinchillas. Never administer.
Hamster: Oral lincosamides cause fatal enterocolitis in hamstersClindamycin and lincomycin are among the antibiotics that induce fatal Clostridium difficile enterocolitis in hamsters. Never administer.
Degu: Oral lincosamides risk fatal dysbiosis in degusExtrapolated from chinchillas and guinea pigs (shared caviomorph hindgut physiology): oral clindamycin/lincomycin should be treated as contraindicated in degus.

Lincomycin is dosed at 15–25 mg/kg PO q12h in dogs, per LINCOCIN® TABLETS- Lincomycin Hydrochloride Monohydrate Tablet [US Product Label]. Kalamazoo, MI: Zoetis Inc; 2017. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.788 (2026-08-01).. Verify against current literature before clinical use.

Backed by 2 published sources

· LINCOCIN® TABLETS- Lincomycin Hydrochloride Monohydrate Tablet [US Product Label]. Kalamazoo, MI: Zoetis Inc; 2017. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.788 (2026-08-01).
· Plumb's Veterinary Drug Handbook, 9th Ed, Lincomycin, DOGS, printed p.761 (lookup p.788); superscript 8 → LINCOCIN - Lincomycin Hydrochloride Monohydrate Liquid (Solution) [US Product Label]. Kalamazoo, MI: Zoetis Inc; 2019 (resolved via plumbref). Independently corroborated: BSAVA Small Animal Formulary 10th Ed printed p.231 (lookup p.247): "Dogs, Cats: Parenteral: 22 mg/kg i.m. q24h or 11 mg/kg i.m. q12h or 11-22 mg/kg slow i.v. q12-24h."

Sample dosing (2 of 2 cited rules)

A dog/cat sample is shown here. Cited dosing for all 1 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.

Species	Route	Dose	Frequency	Evidence	Source
Dog (Domestic)	PO	15–25 mg/kg	q12h	Moderate	LINCOCIN® TABLETS- Lincomycin Hydrochloride Monohydrate Tablet [US Product Label]. Kalamazoo, MI: Zoetis Inc; 2017. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.788 (2026-08-01).
Dog (Domestic)	IM	11 mg/kg	q12h (label alternative: 22 mg/kg IM q24h)	Moderate	Plumb's Veterinary Drug Handbook, 9th Ed, Lincomycin, DOGS, printed p.761 (lookup p.788); superscript 8 → LINCOCIN - Lincomycin Hydrochloride Monohydrate Liquid (Solution) [US Product Label]. Kalamazoo, MI: Zoetis Inc; 2019 (resolved via plumbref). Independently corroborated: BSAVA Small Animal Formulary 10th Ed printed p.231 (lookup p.247): "Dogs, Cats: Parenteral: 22 mg/kg i.m. q24h or 11 mg/kg i.m. q12h or 11-22 mg/kg slow i.v. q12-24h."

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Lincomycin

Drug Class

Routes

Indications

Mechanism of Action

Side effects & warnings

Species with Lincomycin dosing data (2 dose rules)

Evidence levels across 2 dose rules

Backed by 2 published sources

Sample dosing (2 of 2 cited rules)

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Lincomycin

Drug Class

Routes

Indications

Mechanism of Action

Side effects & warnings

Species with Lincomycin dosing data (2 dose rules)

Evidence levels across 2 dose rules

Backed by 2 published sources

Sample dosing (2 of 2 cited rules)

Upgrade for Full Details

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