ExoticRx · exoticrx.com/drugs/mechlorethamine
Mustargen
Bifunctional alkylating agent that forms inter-strand DNA cross-links, preventing DNA strand separation and replication. Highly reactive — acts within minutes.
Severe vesicant — extravasation is a medical emergency. Potent myelosuppression. Strong emetogen. Used in MOPP protocol for lymphoma and topically for cutaneous lymphoma.
Species references:All Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 1 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IV | 3 mg/kg | 3mg/m2 IV on days 1 and 8 of 28-day cycle | Moderate | Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed |
| Dog (Domestic) | Topical | 0 mg/kg | Apply 10-20mg/dL solution to lesions q24h | Moderate | Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.