Question 1

What routes can Mesna be administered by?

Accepted Answer

Available routes: IV, PO.

Question 2

Is Mesna a controlled substance?

Accepted Answer

Mesna is not federally scheduled in the US. Controlled-drug status differs by country — verify your local rules.

Question 3

What are the warnings or contraindications for Mesna?

Accepted Answer

Always co-administer with ifosfamide. Also used with high-dose cyclophosphamide. Does not affect antitumor activity. GI upset with oral form. Given at 0, 4, and 8 hours after alkylating agent.

Question 4

What are the side effects of Mesna?

Accepted Answer

Reported side effects, adverse reactions, and contraindications for Mesna: Always co-administer with ifosfamide. Also used with high-dose cyclophosphamide. Does not affect antitumor activity. GI upset with oral form. Given at 0, 4, and 8 hours after alkylating agent.

Question 5

How does Mesna work?

Accepted Answer

Thiol compound that binds and inactivates acrolein (toxic metabolite of cyclophosphamide and ifosfamide) in the urine, preventing hemorrhagic cystitis.

Mesna

Drug Class

Routes

Mechanism of Action

Side effects & warnings

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