Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Mexiletine is used in dog for Ventricular arrhythmias. Routes documented in dog: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Mexiletine in dog, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Mexitil
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 4–8 mg/kg | q8h | Long-term (arrhythmia management) | Ventricular arrhythmias | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed |
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Blocks fast sodium channels, reducing phase 0 depolarization in ventricular myocytes. Shortens action potential duration.
Often used in combination with sotalol or atenolol for refractory ventricular arrhythmias. GI side effects (give with food). Monitor ECG. Dogs primarily.
Species-specific contraindications and adverse-reaction reports for dog may differ from canine / feline reference data — consult the primary citations listed with each rule.
Why a species-specific page? Mexiletine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dog — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.