ExoticRx · exoticrx.com/drugs/minocycline
US brand names:Minocin
Minocycline is dosed at 5–12.5 mg/kg PO q12h in dogs, per Papich Handbook of Veterinary Drugs, 5th Ed. Verify against current literature before clinical use.
Inhibits protein synthesis by binding 30S ribosomal subunit. More lipophilic than doxycycline with excellent tissue penetration including CNS.
Vestibular toxicity (ataxia, nausea) more common than with doxycycline. Tooth discoloration in young animals. Photosensitivity.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 5–12.5 mg/kg | q12h | Moderate | Papich Handbook of Veterinary Drugs, 5th Ed |
| Cat (Domestic) | PO | 5–12.5 mg/kg | q12h | Moderate | Tynan BE, Papich MG, Kerl ME, Cohn LA. Pharmacokinetics of minocycline in domestic cats. J Feline Med Surg. 2016;18:257-263. doi:10.1177/1098612x15579114 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.920 (2026-08-01). |
Upgrade to Pro or Student to unlock the full dose ranges and frequency for every species. The drug's mechanism, warnings, indications, and cited sources are free to read.
View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.