Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Misoprostol is dosed at 2–5 mcg/kg PO q8-12h in dogs, per Ward DM, Leib MS, Johnston SA, Marini M. The effect of dosing interval on the efficacy of misoprostol in the prevention of aspirin-induced gastric injury. Journal of Veterinary Internal Medicine. 2003;17(3):282-290. doi:10.1111/j.1939-1676.2003.tb02449.x — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.924 (2026-08-01). — Plumb's 10th ed (held) printed p.896, Misoprostol monograph spanning p.896-898; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Misoprostol is used in dogs for GI protection during NSAID therapy. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Misoprostol in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Cytotec
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 2–5 mcg/kg | q8-12h | Duration of NSAID use | GI protection during NSAID therapy | Moderate | Ward DM, Leib MS, Johnston SA, Marini M. The effect of dosing interval on the efficacy of misoprostol in the prevention of aspirin-induced gastric injury. Journal of Veterinary Internal Medicine. 2003;17(3):282-290. doi:10.1111/j.1939-1676.2003.tb02449.x — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.924 (2026-08-01). — Plumb's 10th ed (held) printed p.896, Misoprostol monograph spanning p.896-898; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mcg/kg) | Route | Source | As printed |
|---|---|---|---|
| 5 | PO | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.287 | • Protection against NSAID-induced gastric ulceration: 2-5 μg (micrograms)/kg p.o. q8-12h. |
| 3–6 | PO | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.287 | 3-6 μg/kg p.o. q8h has been suggested |
| 2–5 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.566 | • 2-5 mcg/kg q12h PO. • Dose has not been established. |
| 5 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.566 | • Atopic dermatitis: 5 mcg/kg q8h PO. |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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Synthetic prostaglandin E1 analog that replaces protective prostaglandins depleted by NSAIDs. Enhances mucosal blood flow, mucus/bicarbonate secretion, and epithelial repair.
ABORTIFACIENT — CONTRAINDICATED in pregnant animals and women handling tablets. Diarrhea common (usually transient). Used as GI protectant with chronic NSAID therapy.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Misoprostol dose range in dogs, with cited source references: PO 2–5 mcg/kg q8-12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Misoprostol in dogs: PO.
Cited course lengths for Misoprostol in dogs include: Duration of NSAID use. Duration depends on the indication — match it to the specific dose rule in the table above.
Misoprostol is indicated in dogs for: GI protection during NSAID therapy.
These are general warnings for Misoprostol across species; consult the dog dosing table above for species-specific guidance. ABORTIFACIENT — CONTRAINDICATED in pregnant animals and women handling tablets. Diarrhea common (usually transient). Used as GI protectant with chronic NSAID therapy.
Why a species-specific page? Misoprostol pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.