Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Misoprostol is dosed at 2–5 mcg/kg PO q8-12h in dogs, per Ward DM, Leib MS, Johnston SA, Marini M. The effect of dosing interval on the efficacy of misoprostol in the prevention of aspirin-induced gastric injury. Journal of Veterinary Internal Medicine. 2003;17(3):282-290. doi:10.1111/j.1939-1676.2003.tb02449.x — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.924 (2026-08-01).. Misoprostol is used in dogs for GI protection during NSAID therapy. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Misoprostol in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Cytotec
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 2–5 mcg/kg | q8-12h | Duration of NSAID use | GI protection during NSAID therapy | Moderate | Ward DM, Leib MS, Johnston SA, Marini M. The effect of dosing interval on the efficacy of misoprostol in the prevention of aspirin-induced gastric injury. Journal of Veterinary Internal Medicine. 2003;17(3):282-290. doi:10.1111/j.1939-1676.2003.tb02449.x — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.924 (2026-08-01). |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Synthetic prostaglandin E1 analog that replaces protective prostaglandins depleted by NSAIDs. Enhances mucosal blood flow, mucus/bicarbonate secretion, and epithelial repair.
ABORTIFACIENT — CONTRAINDICATED in pregnant animals and women handling tablets. Diarrhea common (usually transient). Used as GI protectant with chronic NSAID therapy.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Misoprostol dose range in dogs, with cited source references: PO 2–5 mcg/kg q8-12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Misoprostol in dogs: PO.
Cited course lengths for Misoprostol in dogs include: Duration of NSAID use. Duration depends on the indication — match it to the specific dose rule in the table above.
Misoprostol is indicated in dogs for: GI protection during NSAID therapy.
These are general warnings for Misoprostol across species; consult the dog dosing table above for species-specific guidance. ABORTIFACIENT — CONTRAINDICATED in pregnant animals and women handling tablets. Diarrhea common (usually transient). Used as GI protectant with chronic NSAID therapy.
Why a species-specific page? Misoprostol pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.