ExoticRx · exoticrx.com/drugs/misoprostol
US brand names:Cytotec
Misoprostol is dosed at 2–5 mcg/kg PO q8-12h in dogs, per Ward DM, Leib MS, Johnston SA, Marini M. The effect of dosing interval on the efficacy of misoprostol in the prevention of aspirin-induced gastric injury. Journal of Veterinary Internal Medicine. 2003;17(3):282-290. doi:10.1111/j.1939-1676.2003.tb02449.x — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.924 (2026-08-01).. Verify against current literature before clinical use.
Synthetic prostaglandin E1 analog that replaces protective prostaglandins depleted by NSAIDs. Enhances mucosal blood flow, mucus/bicarbonate secretion, and epithelial repair.
ABORTIFACIENT — CONTRAINDICATED in pregnant animals and women handling tablets. Diarrhea common (usually transient). Used as GI protectant with chronic NSAID therapy.
Species references:All Dog (Domestic) drugs
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| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 2–5 mcg/kg | q8-12h | Moderate | Ward DM, Leib MS, Johnston SA, Marini M. The effect of dosing interval on the efficacy of misoprostol in the prevention of aspirin-induced gastric injury. Journal of Veterinary Internal Medicine. 2003;17(3):282-290. doi:10.1111/j.1939-1676.2003.tb02449.x — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.924 (2026-08-01). |
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