Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Nitrofurantoin is dosed at 4.4–5 mg/kg PO q8h in dogs, per Weese JS, Blondeau J, Boothe D, et al. International Society for Companion Animal Infectious Diseases (ISCAID) guidelines for the diagnosis and management of bacterial urinary tract infections in dogs and cats. Vet J. 2019;247:8-25. doi:10.1016/j.tvjl.2019.02.008 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.964 (2026-08-01).. Nitrofurantoin is used in dogs for Lower UTI (cystitis). Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Nitrofurantoin in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Macrodantin
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 4.4–5 mg/kg | q8h | 7-14 days | Lower UTI (cystitis) | Moderate | Weese JS, Blondeau J, Boothe D, et al. International Society for Companion Animal Infectious Diseases (ISCAID) guidelines for the diagnosis and management of bacterial urinary tract infections in dogs and cats. Vet J. 2019;247:8-25. doi:10.1016/j.tvjl.2019.02.008 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.964 (2026-08-01). |
Need the exact dose for your patient?
These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Reduced by bacterial enzymes to reactive intermediates that damage DNA, ribosomes, and other macromolecules. Concentrated in urine.
Only effective for lower urinary tract infections (requires urinary concentration). GI upset common. Avoid in renal failure (inadequate urinary concentration). Pulmonary toxicity rare.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Nitrofurantoin dose range in dogs, with cited source references: PO 4.4–5 mg/kg q8h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Nitrofurantoin in dogs: PO.
Cited course lengths for Nitrofurantoin in dogs include: 7-14 days. Duration depends on the indication — match it to the specific dose rule in the table above.
Nitrofurantoin is indicated in dogs for: Lower UTI (cystitis).
These are general warnings for Nitrofurantoin across species; consult the dog dosing table above for species-specific guidance. Only effective for lower urinary tract infections (requires urinary concentration). GI upset common. Avoid in renal failure (inadequate urinary concentration). Pulmonary toxicity rare.
Why a species-specific page? Nitrofurantoin pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.