Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Oxacillin is dosed at 22–40 mg/kg IV q8h in dogs, per Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted), printed p.964 (corpus pdf p.991), Oxacillin, DOGS/CATS: 'Susceptible infections (extra-label): 22 - 40 mg/kg SC, IM, or IV every 8 hours'. Corroborated by Papich, Saunders Handbook of Veterinary Drugs, 5th ed, printed p.586 (corpus pdf p.614), Oxacillin, Dogs and Cats: '22-40 mg/kg q8h PO.' — EDITION UNVERIFIABLE 2026-08-07: this citation names Papich 5th ed, which is NOT held. Its page locator does not resolve to a page naming this drug in the held 4th ed (2016), so the reference cannot be confirmed against any copy available here. Treat the page number as unchecked and consult the 5th edition directly. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207; Saunders Handbook of Veterinary Drugs — ISBN 9780323244855, https://openlibrary.org/isbn/9780323244855. Oxacillin is used in dogs for Staphylococcal infections. Routes documented in dogs: IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Oxacillin in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Bactocill
Contraindicated in Rabbit, Guinea Pig, Chinchilla, Hamster, Degu
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 22–40 mg/kg | q8h | 7-14 days | Staphylococcal infections | Weak | Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted), printed p.964 (corpus pdf p.991), Oxacillin, DOGS/CATS: 'Susceptible infections (extra-label): 22 - 40 mg/kg SC, IM, or IV every 8 hours'. Corroborated by Papich, Saunders Handbook of Veterinary Drugs, 5th ed, printed p.586 (corpus pdf p.614), Oxacillin, Dogs and Cats: '22-40 mg/kg q8h PO.' — EDITION UNVERIFIABLE 2026-08-07: this citation names Papich 5th ed, which is NOT held. Its page locator does not resolve to a page naming this drug in the held 4th ed (2016), so the reference cannot be confirmed against any copy available here. Treat the page number as unchecked and consult the 5th edition directly. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207; Saunders Handbook of Veterinary Drugs — ISBN 9780323244855, https://openlibrary.org/isbn/9780323244855 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 22–40 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.614 | • 22-40 mg/kg q8h PO. |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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Penicillinase-resistant penicillin. Resists staphylococcal beta-lactamase. Narrow spectrum targeting methicillin-susceptible staphylococci.
Parenteral administration only. Interstitial nephritis possible. Not effective against MRSA. Hepatotoxicity rare.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Oxacillin dose range in dogs, with cited source references: IV 22–40 mg/kg q8h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Oxacillin in dogs: IV.
Cited course lengths for Oxacillin in dogs include: 7-14 days. Duration depends on the indication — match it to the specific dose rule in the table above.
Oxacillin is indicated in dogs for: Staphylococcal infections.
These are general warnings for Oxacillin across species; consult the dog dosing table above for species-specific guidance. Parenteral administration only. Interstitial nephritis possible. Not effective against MRSA. Hepatotoxicity rare.
Why a species-specific page? Oxacillin pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.