ExoticRx · exoticrx.com/drugs/paclitaxel
Paclitaxel
Taxol
Drug Class
Routes
Indications
Mechanism of Action
Promotes microtubule assembly and stabilizes formed microtubules, preventing depolymerization. Arrests cells in G2/M phase by disrupting mitotic spindle function.
Side effects & warnings
Anaphylaxis from Cremophor EL vehicle — premedicate with corticosteroids and antihistamines. Myelosuppression and peripheral neuropathy. Requires slow IV infusion.
Species with Paclitaxel dosing data (2 dose rules)
Species references:All Dog (Domestic) drugs
Evidence levels across 2 dose rules
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
Backed by a published source
- · Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed
Sample dosing (2 of 2 cited rules)
A dog/cat sample is shown here. Cited dosing for all 1 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IV | 132–170 mg/kg | 132-170mg/m2 IV over 2-3 hours q21 days | Moderate | Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed |
| Dog (Domestic) | IV | 132–170 mg/kg | 132-170mg/m2 IV over 3h q21 days x 4-6 cycles | Weak | Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed |
Upgrade for Full Details
Upgrade to Pro or Student to unlock the full dose ranges and frequency for every species. The drug's mechanism, warnings, indications, and cited sources are free to read.
View PlansMore Oncology drugs
Source citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.