What is Pantoprazole used for?

Pantoprazole is indicated for: Acute GI bleeding.

Which species have cited Pantoprazole dosing data?

Pantoprazole dosing in the ExoticRx formulary covers 2 species: Cat (Domestic), Dog (Domestic).

Is Pantoprazole a controlled substance?

Pantoprazole is not federally scheduled in the US. Controlled-drug status differs by country — verify your local rules.

Pantoprazole

US brand names:Protonix

Calculate dosage

Sourced from published veterinary references. Awaiting credentialed clinical reviewer — our editorial process.

Pantoprazole is dosed at 0.7–1 mg/kg IV q12-24h in dogs, per Kuhl A, Odunayo A, Price J, et al. Comparative analysis of the effect of IV administered acid suppressants on gastric pH in dogs. J Vet Intern Med. 2020;34(2):678-683. doi:10.1111/jvim.15718 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1011 (2026-08-01).. Verify against current literature before clinical use.

Drug Class

Gastrointestinal

Routes

POIV

Indications

Acute GI bleeding

Mechanism of Action

Irreversibly inhibits H+/K+ ATPase proton pump. IV formulation particularly useful in critically ill animals unable to take oral medications.

Side effects & warnings

IV form available for hospitalized patients. Fewer drug interactions than omeprazole. Long-term use may affect mineral absorption.

Species with Pantoprazole dosing data (2 dose rules)

Cat (Domestic)Dog (Domestic)

Species references:All Cat (Domestic) drugs All Dog (Domestic) drugs

Evidence levels across 2 dose rules

Moderate×1Weak×1

Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.

Backed by 2 published sources

· Kuhl A, Odunayo A, Price J, et al. Comparative analysis of the effect of IV administered acid suppressants on gastric pH in dogs. J Vet Intern Med. 2020;34(2):678-683. doi:10.1111/jvim.15718 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1011 (2026-08-01).
· Tolbert MK, Odunayo A, Howell RS, Peters EE, Reed A. Efficacy of intravenous administration of combined acid suppressants in healthy dogs. J Vet Intern Med. 2015;29(2):556-560. doi:10.1111/jvim.12555 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1011 (2026-08-01).

Sample dosing (2 of 2 cited rules)

A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.

Species	Route	Dose	Frequency	Evidence	Source
Dog (Domestic)	IV	0.7–1 mg/kg	q12-24h	Moderate	Kuhl A, Odunayo A, Price J, et al. Comparative analysis of the effect of IV administered acid suppressants on gastric pH in dogs. J Vet Intern Med. 2020;34(2):678-683. doi:10.1111/jvim.15718 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1011 (2026-08-01).
Cat (Domestic)	IV	0.7–1 mg/kg	q12-24h	Weak	Tolbert MK, Odunayo A, Howell RS, Peters EE, Reed A. Efficacy of intravenous administration of combined acid suppressants in healthy dogs. J Vet Intern Med. 2015;29(2):556-560. doi:10.1111/jvim.12555 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1011 (2026-08-01).

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