ExoticRx · exoticrx.com/drugs/phenobarbital
Luminal, Solfoton
Enhances GABA-A receptor activity by prolonging chloride channel opening. Also blocks AMPA/glutamate receptors. Raises seizure threshold.
First-line anticonvulsant for dogs. Hepatotoxicity with chronic use (monitor liver enzymes and serum levels). PU/PD, polyphagia, sedation (often transient). Hepatic enzyme inducer (many drug interactions). DEA controlled.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugsAll Rabbit (Domestic) drugs
Controlled substance
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