ExoticRx · exoticrx.com/drugs/ponazuril
US brand names:Marquis
Ponazuril is dosed at 20 mg/kg PO q24h in rabbits, per Allen KE, Little SE, Johnson EM, Hostetler J, Panciera RJ, Ewing SA. Treatment of Hepatozoon americanum infection: review of the literature and experimental evaluation of efficacy. Vet Ther. 2010;11(4):E1-E8. PMID: 21308664 — Plumb's 10th ed printed p.1042, Ponazuril monograph spanning p.1041-1042. Verify against current literature before clinical use.
Inhibits coccidian parasite mitochondrial electron transport, disrupting energy production. Active metabolite of toltrazuril.
Marketed for horses (EPM); used off-label in other species. Palatability may be poor. Compounded suspensions should be verified for stability.
Species references:All African Grey Parrot drugsAll Ball Python drugsAll Cat (Domestic) drugsAll Dog (Domestic) drugsAll Domestic Pigeon drugsAll Guinea Pig drugsAll Pet Rat drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 9 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 20–50 mg/kg | q24h | Moderate | Litster AL, Nichols J, Hall K, Camp J, Mohamed AS. Use of ponazuril paste to treat coccidiosis in shelter-housed cats and dogs. Veterinary Parasitology. 2014;202(3-4):319-325. doi:10.1016/j.vetpar.2014.03.003 / 13. CAPC. Companion Animal Parasite Council Recommendations: Coccidia. Published 2016. doi:10.1016/j.vetpar.2014.03.003 — Plumb's 10th ed printed p.1041, Ponazuril monograph spanning p.1041-1042. |
| Cat (Domestic) | PO | 20 mg/kg | q24h | Moderate | CAPC. Companion Animal Parasite Council Recommendations: Coccidia. Published 2016. Accessed November 29, 2021. — Plumb's 10th ed printed p.1041, Ponazuril monograph spanning p.1041-1042. — Plumb's Veterinary Drug Handbook, 10th ed, Ponazuril monograph, printed p.1042, DOGS/CATS: "Coccidiosis (extra-label): a) 20 mg/kg PO once daily for 3 days. c) 30 mg/kg PO given on days 0 […]" Corroborated: Papich MG, Saunders Handbook of Veterinary Drugs, 4th ed, Ponazuril, Small Animal Dosage, Cats: "Treatment of toxoplasmosis: 20 mg/kg PO q24h." |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.