Question 1

What is Ponazuril used for?

Accepted Answer

Ponazuril is indicated for: Coccidiosis, Coccidiosis (Eimeria), Coccidiosis (Isospora), Cryptosporidiosis, Eimeria stiedae (hepatic coccidiosis), Hepatic coccidiosis, Intestinal coccidia (puppies), Neospora, Neospora caninum, Toxoplasma, Toxoplasma gondii.

Question 2

What routes can Ponazuril be administered by?

Accepted Answer

Available routes: PO.

Question 3

Which species have cited Ponazuril dosing data?

Accepted Answer

Ponazuril dosing in the ExoticRx formulary covers 7 species: African Grey Parrot, Ball Python, Bearded Dragon, Cat (Domestic), Dog (Domestic), Guinea Pig, Rabbit (Domestic).

Question 4

Is Ponazuril a controlled substance?

Accepted Answer

Ponazuril is not federally scheduled as a controlled substance, but is veterinary prescription only in most jurisdictions.

Question 5

What are the warnings or contraindications for Ponazuril?

Accepted Answer

Marketed for horses (EPM); used off-label in other species. Palatability may be poor. Compounded suspensions should be verified for stability.

Question 6

What are the side effects of Ponazuril?

Accepted Answer

Reported side effects, adverse reactions, and contraindications for Ponazuril: Marketed for horses (EPM); used off-label in other species. Palatability may be poor. Compounded suspensions should be verified for stability.

Question 7

How does Ponazuril work?

Accepted Answer

Inhibits coccidian parasite mitochondrial electron transport, disrupting energy production. Active metabolite of toltrazuril.

Species	Route	Dose	Frequency	Evidence	Source
Cat (Domestic)	PO	20–30 mg/kg	q24h	Moderate	Plumb's Veterinary Drug Handbook, 9th Ed
Cat (Domestic)	PO	20–50 mg/kg	q24h	Moderate	Plumb's Veterinary Drug Handbook, 9th Ed

Ponazuril

Drug Class

Routes

Indications

Mechanism of Action

Side effects & warnings

Species with Ponazuril dosing data (13 dose rules)

Evidence levels across 13 dose rules

Backed by 2 published sources

Sample dosing (2 of 13 cited rules)

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