Which species have cited Ponazuril dosing data?

Ponazuril dosing in the ExoticRx formulary covers 7 species: African Grey Parrot, Ball Python, Bearded Dragon, Cat (Domestic), Dog (Domestic), Guinea Pig, Rabbit (Domestic).

Is Ponazuril a controlled substance?

Ponazuril is not federally scheduled in the US. Controlled-drug status differs by country — verify your local rules.

Ponazuril

US brand names:Marquis

Calculate dosage

Sourced from published veterinary references. Awaiting credentialed clinical reviewer — our editorial process.

Ponazuril is dosed at 5–10 mg/kg PO q48h in ball pythons, per Carpenter's Exotic Animal Formulary, 6th Ed. Verify against current literature before clinical use.

Drug Class

Antiparasitic

Routes

Indications

Coccidiosis Coccidiosis (Eimeria)Coccidiosis (Isospora)Cryptosporidiosis Eimeria stiedae (hepatic coccidiosis)Hepatic coccidiosis Intestinal coccidia (puppies)NeosporaNeospora caninumToxoplasmaToxoplasma gondii

Mechanism of Action

Inhibits coccidian parasite mitochondrial electron transport, disrupting energy production. Active metabolite of toltrazuril.

Side effects & warnings

Marketed for horses (EPM); used off-label in other species. Palatability may be poor. Compounded suspensions should be verified for stability.

Species with Ponazuril dosing data (13 dose rules)

African Grey Parrot Ball Python Bearded Dragon Cat (Domestic)Dog (Domestic)Guinea Pig Rabbit (Domestic)

Species references:All African Grey Parrot drugs All Ball Python drugs All Bearded Dragon drugs All Cat (Domestic) drugs All Dog (Domestic) drugs All Guinea Pig drugs All Rabbit (Domestic) drugs

Evidence levels across 13 dose rules

Moderate×9Weak×2Extrapolated×2

Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.

Backed by 8 published sources

· Allen KE, Little SE, Johnson EM, Hostetler J, Panciera RJ, Ewing SA. Treatment of Hepatozoon americanum infection: review of the literature and experimental evaluation of efficacy. Vet Ther. 2010;11(4):E1-E8. PMID: 21308664 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1069 (2026-08-01).
· CAPC. Companion Animal Parasite Council Recommendations: Coccidia. Published 2016. Accessed November 29, 2021. https://capcvet.org/guidelines/american-canine-hepatozoonosis/ — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1069 (2026-08-01).
· Carpenter's Exotic Animal Formulary, 6th Ed
· Carpenter's Exotic Animal Formulary, 6th Ed, avian antiparasitic table, p.439 — Ponazuril 'most species' row, ref 143 = Carpenter JW, Hawkins MG, Barron H. Appendix 1: Table of common drugs and approximate doses. In: Speer B, ed. Current Therapy in Avian Medicine and Surgery; Elsevier; 2016:795-824

Sample dosing (2 of 13 cited rules)

A dog/cat sample is shown here. Cited dosing for all 7 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.

Species	Route	Dose	Frequency	Evidence	Source
Dog (Domestic)	PO	20–50 mg/kg	q24h	Moderate	Litster AL, Nichols J, Hall K, Camp J, Mohamed AS. Use of ponazuril paste to treat coccidiosis in shelter-housed cats and dogs. Veterinary Parasitology. 2014;202(3-4):319-325. doi:10.1016/j.vetpar.2014.03.003 / 13. CAPC. Companion Animal Parasite Council Recommendations: Coccidia. Published 2016. doi:10.1016/j.vetpar.2014.03.003 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1069 (2026-08-01).
Cat (Domestic)	PO	20–30 mg/kg	q24h	Moderate	CAPC. Companion Animal Parasite Council Recommendations: Coccidia. Published 2016. Accessed November 29, 2021. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1069 (2026-08-01).

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