ExoticRx · exoticrx.com/drugs/ponazuril
US brand names:Marquis
Ponazuril is dosed at 5–10 mg/kg PO q48h in ball pythons, per Carpenter's Exotic Animal Formulary, 6th Ed — Carpenter's Exotic Animal Formulary 6th ed, Table 9.2 (Antiparasitic Agents Used in Rodents). Located 2026-08-05: the only table covering this species in which the drug's own row prints this dose. The copy held is an ebook conversion with no printed page numbers, so the table is the citable location. — SOURCE EDITION: Carpenter's Exotic Animal Formulary — ISBN 9780323833929, https://openlibrary.org/isbn/9780323833929. Verify against current literature before clinical use.
Inhibits coccidian parasite mitochondrial electron transport, disrupting energy production. Active metabolite of toltrazuril.
Marketed for horses (EPM); used off-label in other species. Palatability may be poor. Compounded suspensions should be verified for stability.
Species references:All African Grey Parrot drugsAll Ball Python drugsAll Cat (Domestic) drugsAll Dog (Domestic) drugsAll Domestic Pigeon drugsAll Guinea Pig drugsAll Pet Rat drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 9 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 20–50 mg/kg | q24h | Moderate | Litster AL, Nichols J, Hall K, Camp J, Mohamed AS. Use of ponazuril paste to treat coccidiosis in shelter-housed cats and dogs. Veterinary Parasitology. 2014;202(3-4):319-325. doi:10.1016/j.vetpar.2014.03.003 / 13. CAPC. Companion Animal Parasite Council Recommendations: Coccidia. Published 2016. doi:10.1016/j.vetpar.2014.03.003 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1069 (2026-08-01). — Plumb's 10th ed (held) printed p.1041, Ponazuril monograph spanning p.1041-1042; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
| Cat (Domestic) | PO | 20 mg/kg | q24h |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.
| Moderate |
| CAPC. Companion Animal Parasite Council Recommendations: Coccidia. Published 2016. Accessed November 29, 2021. https://capcvet.org/guidelines/american-canine-hepatozoonosis/ — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1069 (2026-08-01). — Plumb's 10th ed (held) printed p.1041, Ponazuril monograph spanning p.1041-1042; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 — Plumb's Veterinary Drug Handbook, 10th ed (held), Ponazuril monograph, printed p.1042 (corpus PDF p.1069), DOGS/CATS: "Coccidiosis (extra-label): a) 20 mg/kg PO once daily for 3 days ... c) 30 mg/kg PO given on days 0 […]" Corroborated: Papich MG, Saunders Handbook of Veterinary Drugs, 4th ed, Ponazuril, Small Animal Dosage, Cats: "Treatment of toxoplasmosis: 20 mg/kg PO q24h." [CEILING REDUCED 2026-08-12, two readers — the served 30 belongs to a two-dose days-0-and-7 regimen, not to a daily one.] |