Cat · Felis catus · typical adult weight 2.50–7.00 kg
Ponazuril is dosed at 20 mg/kg PO q24h in cats, per CAPC. Companion Animal Parasite Council Recommendations: Coccidia. Published 2016. Accessed November 29, 2021. https://capcvet.org/guidelines/american-canine-hepatozoonosis/ — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1069 (2026-08-01). — Plumb's 10th ed (held) printed p.1041, Ponazuril monograph spanning p.1041-1042; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 — Plumb's Veterinary Drug Handbook, 10th ed (held), Ponazuril monograph, printed p.1042 (corpus PDF p.1069), DOGS/CATS: "Coccidiosis (extra-label): a) 20 mg/kg PO once daily for 3 days ... c) 30 mg/kg PO given on days 0 […]" Corroborated: Papich MG, Saunders Handbook of Veterinary Drugs, 4th ed, Ponazuril, Small Animal Dosage, Cats: "Treatment of toxoplasmosis: 20 mg/kg PO q24h." [CEILING REDUCED 2026-08-12, two readers — the served 30 belongs to a two-dose days-0-and-7 regimen, not to a daily one.]. Ponazuril is used in cats for Hepatic coccidiosis, Toxoplasma gondii. Routes documented in cats: PO. A typical adult cat weighs 2.50–7.00 kg. ExoticRx lists 2 cited dose rules for Ponazuril in cats, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Marquis
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 20 mg/kg | q24h | 3-5 days | Hepatic coccidiosis | Moderate | CAPC. Companion Animal Parasite Council Recommendations: Coccidia. Published 2016. Accessed November 29, 2021. https://capcvet.org/guidelines/american-canine-hepatozoonosis/ — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1069 (2026-08-01). — Plumb's 10th ed (held) printed p.1041, Ponazuril monograph spanning p.1041-1042; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 — Plumb's Veterinary Drug Handbook, 10th ed (held), Ponazuril monograph, printed p.1042 (corpus PDF p.1069), DOGS/CATS: "Coccidiosis (extra-label): a) 20 mg/kg PO once daily for 3 days ... c) 30 mg/kg PO given on days 0 […]" Corroborated: Papich MG, Saunders Handbook of Veterinary Drugs, 4th ed, Ponazuril, Small Animal Dosage, Cats: "Treatment of toxoplasmosis: 20 mg/kg PO q24h." [CEILING REDUCED 2026-08-12, two readers — the served 30 belongs to a two-dose days-0-and-7 regimen, not to a daily one.] |
| PO | 20–50 mg/kg | q24h | 7-14 days | Toxoplasma gondii | Moderate | Litster AL, Nichols J, Hall K, Camp J, Mohamed AS. Use of ponazuril paste to treat coccidiosis in shelter-housed cats and dogs. Veterinary Parasitology. 2014;202(3-4):319-325. doi:10.1016/j.vetpar.2014.03.003 / 13. CAPC. Companion Animal Parasite Council Recommendations: Coccidia. Published 2016. Accessed November 29, 2021. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1069 (2026-08-01). — Plumb's 10th ed (held) printed p.1041, Ponazuril monograph spanning p.1041-1042; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 20 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.680 | • Kittens (toxoplasmosis): 50 mg/kg once PO or 20 mg/kg once daily for 2 days PO. |
| 50 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.680 | • Kittens (toxoplasmosis): 50 mg/kg once PO or 20 mg/kg once daily for 2 days PO. |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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These ranges are per kg. Enter your cat's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Inhibits coccidian parasite mitochondrial electron transport, disrupting energy production. Active metabolite of toltrazuril.
Marketed for horses (EPM); used off-label in other species. Palatability may be poor. Compounded suspensions should be verified for stability.
Species-specific contraindications and adverse-reaction reports for cats may differ from canine / feline reference data — consult the primary citations listed with each rule.
Ponazuril dose ranges in cats, with cited source references: PO 20 mg/kg q24h; PO 20–50 mg/kg q24h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Ponazuril in cats: PO.
Cited course lengths for Ponazuril in cats include: 3-5 days; 7-14 days. Duration depends on the indication — match it to the specific dose rule in the table above.
Ponazuril is indicated in cats for: Hepatic coccidiosis, Toxoplasma gondii.
These are general warnings for Ponazuril across species; consult the cat dosing table above for species-specific guidance. Marketed for horses (EPM); used off-label in other species. Palatability may be poor. Compounded suspensions should be verified for stability.
Why a species-specific page? Ponazuril pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in cats — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.