Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Ponazuril is dosed at 20–50 mg/kg PO q24h for 3 days in dogs, per Plumb's Veterinary Drug Handbook, 10th ed., Ponazuril, printed p.1042 (corpus PDF p.1069), DOGS/CATS / Coccidiosis. Plumb's ref 2 = Litster AL, Nichols J, Hall K, Camp J, Mohamed AS. Use of ponazuril paste to treat coccidiosis in shelter-housed cats and dogs. Vet Parasitol. 2014;202(3-4):319-325. doi:10.1016/j.vetpar.2014.03.003 (supports the 50 mg/kg x3-day regimen). Ref 13 = CAPC Coccidia guideline, 2016 (20 mg/kg x3 days).. Ponazuril is used in dogs for Intestinal coccidia (puppies), Coccidiosis, Neospora, Toxoplasma, Neospora caninum. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 3 cited dose rules for Ponazuril in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Marquis
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 20–50 mg/kg | q24h for 3 days | Single dose; repeat in 14 days if needed | Intestinal coccidia (puppies) | Moderate | Plumb's Veterinary Drug Handbook, 10th ed., Ponazuril, printed p.1042 (corpus PDF p.1069), DOGS/CATS / Coccidiosis. Plumb's ref 2 = Litster AL, Nichols J, Hall K, Camp J, Mohamed AS. Use of ponazuril paste to treat coccidiosis in shelter-housed cats and dogs. Vet Parasitol. 2014;202(3-4):319-325. doi:10.1016/j.vetpar.2014.03.003 (supports the 50 mg/kg x3-day regimen). Ref 13 = CAPC Coccidia guideline, 2016 (20 mg/kg x3 days). |
| PO | 20–50 mg/kg | q24h | 1-3 days for coccidia; longer for Neospora | Coccidiosis, Neospora, Toxoplasma | Moderate | Litster AL, Nichols J, Hall K, Camp J, Mohamed AS. Use of ponazuril paste to treat coccidiosis in shelter-housed cats and dogs. Veterinary Parasitology. 2014;202(3-4):319-325. doi:10.1016/j.vetpar.2014.03.003 / 13. CAPC. Companion Animal Parasite Council Recommendations: Coccidia. Published 2016. doi:10.1016/j.vetpar.2014.03.003 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1069 (2026-08-01). |
| PO | 10–20 mg/kg | q24h | 28 days | Neospora caninum | Moderate | CAPC. Companion Animal Parasite Council Recommendations: Coccidia. Published 2016. Accessed November 29, 2021. https://capcvet.org/guidelines/american-canine-hepatozoonosis/ — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1069 (2026-08-01). |
Need the exact dose for your patient?
These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Inhibits coccidian parasite mitochondrial electron transport, disrupting energy production. Active metabolite of toltrazuril.
Marketed for horses (EPM); used off-label in other species. Palatability may be poor. Compounded suspensions should be verified for stability.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Ponazuril dose ranges in dogs, with cited source references: PO 20–50 mg/kg q24h for 3 days; PO 20–50 mg/kg q24h; PO 10–20 mg/kg q24h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Ponazuril in dogs: PO.
Cited course lengths for Ponazuril in dogs include: Single dose; repeat in 14 days if needed; 1-3 days for coccidia; longer for Neospora; 28 days. Duration depends on the indication — match it to the specific dose rule in the table above.
Ponazuril is indicated in dogs for: Intestinal coccidia (puppies), Coccidiosis, Neospora, Toxoplasma, Neospora caninum.
These are general warnings for Ponazuril across species; consult the dog dosing table above for species-specific guidance. Marketed for horses (EPM); used off-label in other species. Palatability may be poor. Compounded suspensions should be verified for stability.
Why a species-specific page? Ponazuril pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.