Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Ponazuril is dosed at 10–20 mg/kg PO q24h in dogs, per CAPC. Companion Animal Parasite Council Recommendations: Coccidia. Published 2016. Accessed November 29, 2021. https://capcvet.org/guidelines/american-canine-hepatozoonosis/ — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1069 (2026-08-01). — Plumb's 10th ed (held) printed p.1041, Ponazuril monograph spanning p.1041-1042; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Ponazuril is used in dogs for Neospora caninum, Coccidiosis (and create a separate rule: Neosporosis or toxoplasmosis, 7.5-15 mg/kg PO q24h for 28 days), Intestinal coccidia (puppies). Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 3 cited dose rules for Ponazuril in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Marquis
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 10–20 mg/kg | q24h | 28 days |
| Neospora caninum |
| Moderate |
| CAPC. Companion Animal Parasite Council Recommendations: Coccidia. Published 2016. Accessed November 29, 2021. https://capcvet.org/guidelines/american-canine-hepatozoonosis/ — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1069 (2026-08-01). — Plumb's 10th ed (held) printed p.1041, Ponazuril monograph spanning p.1041-1042; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
| PO | 20–50 mg/kg | q24h | 1-3 days for coccidia; longer for Neospora | Coccidiosis (and create a separate rule: Neosporosis or toxoplasmosis, 7.5-15 mg/kg PO q24h for 28 days) | Moderate | Litster AL, Nichols J, Hall K, Camp J, Mohamed AS. Use of ponazuril paste to treat coccidiosis in shelter-housed cats and dogs. Veterinary Parasitology. 2014;202(3-4):319-325. doi:10.1016/j.vetpar.2014.03.003 / 13. CAPC. Companion Animal Parasite Council Recommendations: Coccidia. Published 2016. doi:10.1016/j.vetpar.2014.03.003 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1069 (2026-08-01). — Plumb's 10th ed (held) printed p.1041, Ponazuril monograph spanning p.1041-1042; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
| PO | 20–50 mg/kg | q24h for 3 days | Single dose; repeat in 14 days if needed | Intestinal coccidia (puppies) | Moderate | Plumb's Veterinary Drug Handbook, 10th ed., Ponazuril, printed p.1042 (corpus PDF p.1069), DOGS/CATS / Coccidiosis. Plumb's ref 2 = Litster AL, Nichols J, Hall K, Camp J, Mohamed AS. Use of ponazuril paste to treat coccidiosis in shelter-housed cats and dogs. Vet Parasitol. 2014;202(3-4):319-325. doi:10.1016/j.vetpar.2014.03.003 (supports the 50 mg/kg x3-day regimen). Ref 13 = CAPC Coccidia guideline, 2016 (20 mg/kg x3 days). — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 10 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.680 | • 10 mg/kg PO q12h. |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Inhibits coccidian parasite mitochondrial electron transport, disrupting energy production. Active metabolite of toltrazuril.
Marketed for horses (EPM); used off-label in other species. Palatability may be poor. Compounded suspensions should be verified for stability.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Ponazuril dose ranges in dogs, with cited source references: PO 10–20 mg/kg q24h; PO 20–50 mg/kg q24h; PO 20–50 mg/kg q24h for 3 days. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Ponazuril in dogs: PO.
Cited course lengths for Ponazuril in dogs include: 28 days; 1-3 days for coccidia; longer for Neospora; Single dose; repeat in 14 days if needed. Duration depends on the indication — match it to the specific dose rule in the table above.
Ponazuril is indicated in dogs for: Neospora caninum, Coccidiosis (and create a separate rule: Neosporosis or toxoplasmosis, 7.5-15 mg/kg PO q24h for 28 days), Intestinal coccidia (puppies).
These are general warnings for Ponazuril across species; consult the dog dosing table above for species-specific guidance. Marketed for horses (EPM); used off-label in other species. Palatability may be poor. Compounded suspensions should be verified for stability.
Why a species-specific page? Ponazuril pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.