ExoticRx · exoticrx.com/drugs/procainamide
US brand names:Pronestyl, Procanbid
Procainamide is dosed at 2–4 mg/kg IV Slow IV over 2-5 min, max total 20 mg/kg in dogs, per Plumb's Veterinary Drug Handbook, 10th ed (2023) — Plumb's 10th ed printed p.1068, Procainamide monograph spanning p.1068-1070. — Plumb's 10th ed printed p.1070, Procainamide monograph. Verify against current literature before clinical use.
Class IA antiarrhythmic blocking fast sodium channels. Prolongs action potential duration and effective refractory period in atria and ventricles.
GI upset common. Drug-induced lupus (SLE) with chronic use. Monitor CBC, ANA. N-acetylprocainamide (NAPA) metabolite has Class III activity.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IV | 2–4 mg/kg | Slow IV over 2-5 min, max total 20 mg/kg | Strong | Plumb's Veterinary Drug Handbook, 10th ed (2023) — Plumb's 10th ed printed p.1068, Procainamide monograph spanning p.1068-1070. — Plumb's 10th ed printed p.1070, Procainamide monograph.Compilation only — we have not located an independent source that prints this figure. |
| Dog (Domestic) | PO | 10–30 mg/kg | q6-8h | Weak | Papich MG. Saunders Handbook of Veterinary Drugs: Small and Large Animal, 4th ed. (Elsevier, 2016), Procainamide Hydrochloride, printed p.677Compilation only — we have not located an independent source that prints this figure. |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.