Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Procainamide is dosed at 10–30 mg/kg PO q6-8h in dogs, per Papich MG. Saunders Handbook of Veterinary Drugs: Small and Large Animal, 4th ed. (Elsevier, 2016), Procainamide Hydrochloride, printed p.677 (corpus PDF p.705). Procainamide is used in dogs for Ventricular tachyarrhythmias, Ventricular arrhythmias (maintenance). Routes documented in dogs: IV, PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 2 cited dose rules for Procainamide in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Pronestyl, Procanbid
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 2–4 mg/kg | IV bolus over 3-5 min, then CRI 10-40 mcg/kg/min | Until arrhythmia controlled | Ventricular tachyarrhythmias | Strong | Plumb's Veterinary Drug Handbook, 9th Ed |
| PO | 10–30 mg/kg | q6-8h | Long-term |
| Ventricular arrhythmias (maintenance) |
| Moderate |
| Papich MG. Saunders Handbook of Veterinary Drugs: Small and Large Animal, 4th ed. (Elsevier, 2016), Procainamide Hydrochloride, printed p.677 (corpus PDF p.705) |
One of the cited rules is a continuous-rate-infusion regimen: IV 2–4 mg/kg IV bolus over 3-5 min, then CRI 10-40 mcg/kg/min. CRI regimens are delivered as a continuous infusion rather than discrete doses — verify the rate against the cited source before use.
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Class IA antiarrhythmic blocking fast sodium channels. Prolongs action potential duration and effective refractory period in atria and ventricles.
GI upset common. Drug-induced lupus (SLE) with chronic use. Monitor CBC, ANA. N-acetylprocainamide (NAPA) metabolite has Class III activity.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Procainamide dose ranges in dogs, with cited source references: IV 2–4 mg/kg IV bolus over 3-5 min, then CRI 10-40 mcg/kg/min; PO 10–30 mg/kg q6-8h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Procainamide in dogs: IV, PO.
Cited course lengths for Procainamide in dogs include: Until arrhythmia controlled; Long-term. Duration depends on the indication — match it to the specific dose rule in the table above.
Procainamide is indicated in dogs for: Ventricular tachyarrhythmias, Ventricular arrhythmias (maintenance).
These are general warnings for Procainamide across species; consult the dog dosing table above for species-specific guidance. GI upset common. Drug-induced lupus (SLE) with chronic use. Monitor CBC, ANA. N-acetylprocainamide (NAPA) metabolite has Class III activity.
Why a species-specific page? Procainamide pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.