Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Procainamide is dosed at 2–4 mg/kg IV Slow IV over 2-5 min, max total 20 mg/kg in dogs, per Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted) — Plumb's 10th ed (held) printed p.1068, Procainamide monograph spanning p.1068-1070; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — figure located 2026-08-05 at Plumb's 10th ed printed p.1070, Procainamide monograph; the page cited previously does not carry it. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Procainamide is used in dogs for Ventricular tachyarrhythmias, Ventricular arrhythmias (maintenance). Routes documented in dogs: IV, PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 2 cited dose rules for Procainamide in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Pronestyl, Procanbid
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 2–4 mg/kg | Slow IV over 2-5 min, max total 20 mg/kg | Until arrhythmia controlled | Ventricular tachyarrhythmias | Strong | Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted) — Plumb's 10th ed (held) printed p.1068, Procainamide monograph spanning p.1068-1070; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — figure located 2026-08-05 at Plumb's 10th ed printed p.1070, Procainamide monograph; the page cited previously does not carry it. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
| PO | 10–30 mg/kg | q6-8h | Long-term | Ventricular arrhythmias (maintenance) | Weak | Papich MG. Saunders Handbook of Veterinary Drugs: Small and Large Animal, 4th ed. (Elsevier, 2016), Procainamide Hydrochloride, printed p.677 (corpus PDF p.705) — SOURCE EDITION: Saunders Handbook of Veterinary Drugs — ISBN 9780323244855, https://openlibrary.org/isbn/9780323244855 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mcg/kg) | Route | Source | As printed |
|---|---|---|---|
| 20 | IV | Papich Saunders Handbook of Veterinary Drugs, 4th edp.705 | • CRI: Initial loading dose of 10 mg/kg, followed by 20 mcg/kg/min IV CRI; the |
| 25–50 | — | Papich Saunders Handbook of Veterinary Drugs, 4th edp.705 | CRI rate can be increased to 25-50 mcg/kg/min if needed for refractory arrhythmias. |
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 10–30 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.705 | • 10-30 mg/kg q6h PO to a maximum dose of 40 mg/kg. |
Need the exact dose for your patient?
These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Class IA antiarrhythmic blocking fast sodium channels. Prolongs action potential duration and effective refractory period in atria and ventricles.
GI upset common. Drug-induced lupus (SLE) with chronic use. Monitor CBC, ANA. N-acetylprocainamide (NAPA) metabolite has Class III activity.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Procainamide dose ranges in dogs, with cited source references: IV 2–4 mg/kg Slow IV over 2-5 min, max total 20 mg/kg; PO 10–30 mg/kg q6-8h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Procainamide in dogs: IV, PO.
Cited course lengths for Procainamide in dogs include: Until arrhythmia controlled; Long-term. Duration depends on the indication — match it to the specific dose rule in the table above.
Procainamide is indicated in dogs for: Ventricular tachyarrhythmias, Ventricular arrhythmias (maintenance).
These are general warnings for Procainamide across species; consult the dog dosing table above for species-specific guidance. GI upset common. Drug-induced lupus (SLE) with chronic use. Monitor CBC, ANA. N-acetylprocainamide (NAPA) metabolite has Class III activity.
Why a species-specific page? Procainamide pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.
| 40 |
| PO |
| Papich Saunders Handbook of Veterinary Drugs, 4th edp.705 |
| • 10-30 mg/kg q6h PO to a maximum dose of 40 mg/kg. |
| 8–20 | IV | Papich Saunders Handbook of Veterinary Drugs, 4th edp.705 | • 8-20 mg/kg IV or IM. |
| 10 | IV | Papich Saunders Handbook of Veterinary Drugs, 4th edp.705 | • CRI: Initial loading dose of 10 mg/kg, followed by 20 mcg/kg/min IV CRI; the |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.