Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Pyrimethamine is dosed at 0.25–1 mg/kg PO q24h; 0.25-0.5 mg/kg may be given q12h in dogs, per Plumb's Veterinary Drug Handbook, 10th ed., printed p.1100 (corpus PDF p.1127), Dosages > DOGS; corroborated by BSAVA Small Animal Formulary 10th ed., Pyrimethamine, printed p.354 (corpus PDF p.370) - 'Dogs, Cats: Toxoplasmosis/neosporosis: 1 mg/kg p.o. q24h or divided q12h for 4 weeks, alongside sulphonamides'. Pyrimethamine is used in dogs for Toxoplasmosis/Neosporosis. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Pyrimethamine in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Daraprim
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 0.25–1 mg/kg | q24h; 0.25-0.5 mg/kg may be given q12h | 14-28 days; combine with sulfonamide; supplement folinic acid | Toxoplasmosis/Neosporosis | Moderate | Plumb's Veterinary Drug Handbook, 10th ed., printed p.1100 (corpus PDF p.1127), Dosages > DOGS; corroborated by BSAVA Small Animal Formulary 10th ed., Pyrimethamine, printed p.354 (corpus PDF p.370) - 'Dogs, Cats: Toxoplasmosis/neosporosis: 1 mg/kg p.o. q24h or divided q12h for 4 weeks, alongside sulphonamides' |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Inhibits dihydrofolate reductase in protozoa, blocking folic acid synthesis required for DNA replication. Synergistic with sulfonamides.
Bone marrow suppression possible — monitor CBC. Supplement with folinic acid (leucovorin). Teratogenic. Do not use in pregnant animals.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Pyrimethamine dose range in dogs, with cited source references: PO 0.25–1 mg/kg q24h; 0.25-0.5 mg/kg may be given q12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Pyrimethamine in dogs: PO.
Cited course lengths for Pyrimethamine in dogs include: 14-28 days; combine with sulfonamide; supplement folinic acid. Duration depends on the indication — match it to the specific dose rule in the table above.
Pyrimethamine is indicated in dogs for: Toxoplasmosis/Neosporosis.
These are general warnings for Pyrimethamine across species; consult the dog dosing table above for species-specific guidance. Bone marrow suppression possible — monitor CBC. Supplement with folinic acid (leucovorin). Teratogenic. Do not use in pregnant animals.
Why a species-specific page? Pyrimethamine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.