Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Pyrimethamine is used in dog for Toxoplasmosis/Neosporosis. Routes documented in dog: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Pyrimethamine in dog, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Daraprim
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 0.25–1 mg/kg | q12-24h | 14-28 days; combine with sulfonamide; supplement folinic acid | Toxoplasmosis/Neosporosis | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Inhibits dihydrofolate reductase in protozoa, blocking folic acid synthesis required for DNA replication. Synergistic with sulfonamides.
Bone marrow suppression possible — monitor CBC. Supplement with folinic acid (leucovorin). Teratogenic. Do not use in pregnant animals.
Species-specific contraindications and adverse-reaction reports for dog may differ from canine / feline reference data — consult the primary citations listed with each rule.
Why a species-specific page? Pyrimethamine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dog — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.