Pyriproxyfen for Dog
Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Pyriproxyfen is used in dog for Flea prevention (insect growth regulator). Routes documented in dog: Topical. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Pyriproxyfen in dog, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Nylar, Vectra
Dose ranges
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| Topical | 1–5 mg/kg | q30d | Monthly application; year-round in endemic areas | Flea prevention (insect growth regulator) | Strong | Product labels (Vectra, Activyl); FDA openFDA Adverse Event Database |
Need the exact dose for your patient?
These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Mechanism of action
Juvenile hormone analog that mimics insect juvenile hormone, preventing flea eggs from hatching and larvae from developing into adults. Disrupts the flea life cycle without killing adult fleas.
Side effects & warnings
Extremely low mammalian toxicity. Toxic to aquatic invertebrates — keep treated animals away from water bodies. Does not kill adult fleas; combine with adulticide for complete flea control.
Species-specific contraindications and adverse-reaction reports for dog may differ from canine / feline reference data — consult the primary citations listed with each rule.
Other Antiparasitic drugs with dog dosing
Pyriproxyfen dosing in other species
Why a species-specific page? Pyriproxyfen pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dog — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.