Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Ranolazine is dosed at 5–15 mg/kg PO q12h in dogs, per Source not established. The citation previously shown here named no retrievable document; a literature search on 2026-07-31 found no source that states this dose for this species and route. Treat as unverified and confirm against a primary reference before clinical use.. Ranolazine is used in dogs for Ventricular arrhythmias (adjunct). Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Ranolazine in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Ranexa
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 5–15 mg/kg | q12h | Investigational; monitor QT interval | Ventricular arrhythmias (adjunct) | Weak | Source not established. The citation previously shown here named no retrievable document; a literature search on 2026-07-31 found no source that states this dose for this species and route. Treat as unverified and confirm against a primary reference before clinical use. |
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Inhibits late inward sodium current (INaL) during cardiac repolarization, reducing intracellular sodium and calcium overload.
QT prolongation risk. Avoid with strong CYP3A inhibitors. Limited veterinary data — investigational use.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Ranolazine dose range in dogs, with cited source references: PO 5–15 mg/kg q12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Ranolazine in dogs: PO.
Cited course lengths for Ranolazine in dogs include: Investigational; monitor QT interval. Duration depends on the indication — match it to the specific dose rule in the table above.
Ranolazine is indicated in dogs for: Ventricular arrhythmias (adjunct).
These are general warnings for Ranolazine across species; consult the dog dosing table above for species-specific guidance. QT prolongation risk. Avoid with strong CYP3A inhibitors. Limited veterinary data — investigational use.
Why a species-specific page? Ranolazine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.