Question 1

What is Rifampin used for?

Accepted Answer

Rifampin is indicated for: abscess, Mycobacterial infections (combination), Rhodococcus equi (with macrolide), Staphylococcal infections (combination therapy).

Question 2

What routes can Rifampin be administered by?

Accepted Answer

Available routes: PO, IV.

Question 3

Which species have cited Rifampin dosing data?

Accepted Answer

Rifampin dosing in the ExoticRx formulary covers 3 species: Cat (Domestic), Dog (Domestic), Horse (Equine).

Question 4

Is Rifampin a controlled substance?

Accepted Answer

Rifampin is not federally scheduled as a controlled substance, but is veterinary prescription only in most jurisdictions.

Question 5

What are the warnings or contraindications for Rifampin?

Accepted Answer

Always use in combination (rapid resistance when used alone). Potent CYP inducer (many drug interactions). Orange/red discoloration of urine, tears. Hepatotoxic — monitor liver enzymes.

Question 6

What are the side effects of Rifampin?

Accepted Answer

Reported side effects, adverse reactions, and contraindications for Rifampin: Always use in combination (rapid resistance when used alone). Potent CYP inducer (many drug interactions). Orange/red discoloration of urine, tears. Hepatotoxic — monitor liver enzymes.

Question 7

How does Rifampin work?

Accepted Answer

Inhibits bacterial DNA-dependent RNA polymerase, blocking RNA synthesis. Excellent intracellular penetration.

Species	Route	Dose	Frequency	Evidence	Source
Dog (Domestic)	PO	5–10 mg/kg	q12-24h	Moderate	Plumb's Veterinary Drug Handbook, 9th Ed
Cat (Domestic)	PO	10–15 mg/kg	q24h	Weak	BSAVA Small Animal Formulary, 10th Ed

Rifampin

Drug Class

Routes

Indications

Mechanism of Action

Side effects & warnings

Species with Rifampin dosing data (3 dose rules)

Evidence levels across 3 dose rules

Backed by 3 published sources

Sample dosing (2 of 3 cited rules)

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