ExoticRx · exoticrx.com/drugs/selamectin
US brand names:Revolution, Stronghold
Selamectin is dosed at 6–18 mg/kg Topical Repeat at 14d in african pygmy hedgehogs, per ExoticRx 2026 (hedgehog dosing guide); Mori & Hedley, J Exot Pet Med 2019. Verify against current literature before clinical use.
Binds glutamate-gated chloride channels in invertebrate nerve/muscle cells. Absorbed through skin; reaches systemic circulation.
Do not apply to broken skin. Monthly application. Prevents heartworm, kills fleas, treats ear mites, sarcoptic mange. Safe in MDR1 dogs at labeled dose. OK in rabbits and ferrets.
Species references:All African Pygmy Hedgehog drugsAll Cat (Domestic) drugsAll Chinchilla drugsAll Dog (Domestic) drugsAll Dwarf Hamster drugsAll Ferret drugsAll Pet Rat drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 9 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | TOPICAL | 6–12 mg/kg | q30d | Strong | Verified against Papich/Saunders Handbook of Veterinary Drugs, 4th Ed, p.749 (2026-08-01). |
| Cat (Domestic) | TOPICAL | 6–12 mg/kg | q30d | Strong | Koch S, Torres S, Plumb D. Small Animal Dermatology Drug Handbook. Wiley-Blackwell; 2011. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1175 (2026-08-01). |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.