ExoticRx · exoticrx.com/drugs/selamectin
US brand names:Revolution, Stronghold
Selamectin is dosed at 6–15 mg/kg topical q28d x 2 treatments (q14d if Demodex) in degus, per Ewringmann A, Gloeckner B. Leitsymptome bei Hamster, Ratte, Maus und Rennmaus, Enke, Stuttgart, Germany; 2014. | Fehr M, Sassenburg L, Zwart P. Krankheiten der Heimtiere, 8th ed., Schluetersche Verlagsgesellschaft, Hannover, Germany; 2015. — Source: Carpenter's Exotic Animal Formulary, 6th Ed, p.780 — Carpenter's Exotic Animal Formulary 6th ed, Table 9.2 (Antiparasitic Agents Used in Rodents). The copy held is an ebook conversion with no printed page numbers, so the table — not the page — is the citable location. — SOURCE EDITION: Carpenter's Exotic Animal Formulary — ISBN 9780323833929, https://openlibrary.org/isbn/9780323833929. Verify against current literature before clinical use.
Binds glutamate-gated chloride channels in invertebrate nerve/muscle cells. Absorbed through skin; reaches systemic circulation.
Do not apply to broken skin. Monthly application. Prevents heartworm, kills fleas, treats ear mites, sarcoptic mange. Safe in MDR1 dogs at labeled dose. OK in rabbits and ferrets.
Species references:All Cat (Domestic) drugsAll Degu drugsAll Dog (Domestic) drugsAll Dwarf Hamster drugsAll Ferret drugsAll Guinea Pig drugsAll Mouse drugsAll Rabbit (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 9 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | TOPICAL | 6–12 mg/kg | q30d | Strong | Verified against Papich/Saunders Handbook of Veterinary Drugs, 4th Ed, p.749 (2026-08-01). — LOCATOR CONVENTION 2026-08-07: the bare 'p.749' in this citation is the PDF index of the held scan, not the printed page. The PRINTED page is p.721; verified by finding the drug named there. If you are holding the book, turn to p.721. — SOURCE EDITION: Saunders Handbook of Veterinary Drugs — ISBN 9780323244855, https://openlibrary.org/isbn/9780323244855 |
| Cat (Domestic) | TOPICAL | 6–12 mg/kg | q30d | Strong | Koch S, Torres S, Plumb D. Small Animal Dermatology Drug Handbook. Wiley-Blackwell; 2011. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1175 (2026-08-01). — Plumb's 10th ed (held) printed p.1148, Selamectin monograph spanning p.1147-1148; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, ; Muller & Kirk's Small Animal Dermatology — ISBN 9781416000280, | ORIGINAL SOURCE THE BOOK CITES (2026-08-20): the dose row carries superscript 1 — "6 - 13 mg/kg topically every 2 vation and vomiting1 ; anorexia and let" — which resolves in the monograph's own reference list to: REVOLUTION PLUS - Selamectin and Sarolaner Solution [US Product Label for Cats]. Zoetis Inc.; 2019. This records what the handbook attributes the figure to. It is NOT a statement that the reference was read or that it validates the dose. |
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