Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Sulfadiazine is dosed at 15–25 mg/kg PO q12h in dogs, per Weese JS, Blondeau J, Boothe D, et al. International Society for Companion Animal Infectious Diseases (ISCAID) guidelines for the diagnosis and management of bacterial urinary tract infections in dogs and cats. Vet J. 2019;247:8-25. doi:10.1016/j.tvjl.2019.02.008 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1222 (2026-08-01). — Plumb's 10th ed (held) printed p.1195-1196 (corpus PDF p.1222-1223), Sulfa-/Trimethoprim monograph, Dosages (DOGS printed p.1195, CATS printed p.1196); that monograph states "Unless otherwise noted, doses are for combined sulfa-/trimethoprim" [LOCATOR CORRECTED 2026-08-12 — the clause previously here named the Pyrimethamine/Sulfadiazine monograph, whose entire Dosages section is horse-only EPM]; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Sulfadiazine is used in dogs for Susceptible infections (with trimethoprim). Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Sulfadiazine in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 15–25 mg/kg | q12h | 7-14 days | Susceptible infections (with trimethoprim) | Strong | Weese JS, Blondeau J, Boothe D, et al. International Society for Companion Animal Infectious Diseases (ISCAID) guidelines for the diagnosis and management of bacterial urinary tract infections in dogs and cats. Vet J. 2019;247:8-25. doi:10.1016/j.tvjl.2019.02.008 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1222 (2026-08-01). — Plumb's 10th ed (held) printed p.1195-1196 (corpus PDF p.1222-1223), Sulfa-/Trimethoprim monograph, Dosages (DOGS printed p.1195, CATS printed p.1196); that monograph states "Unless otherwise noted, doses are for combined sulfa-/trimethoprim" [LOCATOR CORRECTED 2026-08-12 — the clause previously here named the Pyrimethamine/Sulfadiazine monograph, whose entire Dosages section is horse-only EPM]; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 100 | IV | Papich Saunders Handbook of Veterinary Drugs, 4th edp.778 | • 100 mg/kg IV PO (loading dose), followed by 50 mg/kg q12h IV or PO |
| 50 | IV | Papich Saunders Handbook of Veterinary Drugs, 4th edp.778 | • 100 mg/kg IV PO (loading dose), followed by 50 mg/kg q12h IV or PO |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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Competitive inhibitor of dihydropteroate synthase in folate synthesis pathway. Bacteriostatic alone; bactericidal when combined with trimethoprim.
Ensure adequate hydration to prevent crystalluria. KCS risk in dogs with prolonged use. Avoid in hepatic insufficiency. Folate supplementation may be needed.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Sulfadiazine dose range in dogs, with cited source references: PO 15–25 mg/kg q12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Sulfadiazine in dogs: PO.
Cited course lengths for Sulfadiazine in dogs include: 7-14 days. Duration depends on the indication — match it to the specific dose rule in the table above.
Sulfadiazine is indicated in dogs for: Susceptible infections (with trimethoprim).
These are general warnings for Sulfadiazine across species; consult the dog dosing table above for species-specific guidance. Ensure adequate hydration to prevent crystalluria. KCS risk in dogs with prolonged use. Avoid in hepatic insufficiency. Folate supplementation may be needed.
Why a species-specific page? Sulfadiazine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.