ExoticRx · exoticrx.com/drugs/sunitinib
US brand names:Sutent
Sunitinib is dosed at 2–3 mg/kg PO PO q24h, 4 weeks on / 2 weeks off in dogs, per Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed. Verify against current literature before clinical use.
Inhibits multiple receptor tyrosine kinases: VEGFR-1/2/3, PDGFR-alpha/beta, c-KIT, FLT-3, CSF-1R, and RET. Anti-angiogenic and direct anti-tumor activity.
Cardiotoxicity risk — monitor cardiac function. Hypothyroidism, hypertension, GI toxicity. Yellow skin discoloration. Limited veterinary data.
Species references:All Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 1 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 2–3 mg/kg | PO q24h, 4 weeks on / 2 weeks off | Anecdotal | Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed |
| Dog (Domestic) | PO | 2–3.5 mg/kg | PO q24h on 4 weeks on / 2 weeks off schedule | Anecdotal | Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.