ExoticRx · exoticrx.com/drugs/temozolomide
Temodar
Prodrug that spontaneously converts to MTIC at physiologic pH. Methylates DNA at O6-guanine and N7-guanine, causing cytotoxic DNA damage. Crosses blood-brain barrier.
Good CNS penetration — used for brain tumors. Myelosuppression (thrombocytopenia, neutropenia). Take on empty stomach. Monitor CBC. Used investigationally in dogs for glioma.
Species references:All Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 1 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 60–80 mg/kg | 60-80mg/m2 PO q24h x 5 days per 28-day cycle | Weak | Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed |
| Dog (Domestic) | PO | 60–80 mg/kg | 60-80mg/m2 PO q24h x 5 days q28 days | Anecdotal | Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed |
Upgrade to Pro or Student to unlock the full dose ranges and frequency for every species. The drug's mechanism, warnings, indications, and cited sources are free to read.
View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.