Livestock · Bos taurus · typical adult weight 250.00–900.00 kg
Tildipirosin (Long-Acting) is dosed at 4 mg/kg SC single dose in cattle, per Zuprevo(R) (Tildipirosin 18%) [Product Label]. Merck Animal Health; 2011. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1263 (2026-08-01).. Tildipirosin (Long-Acting) is used in cattle for Bovine respiratory disease. Routes documented in cattle: SC. A typical adult cattle weighs 250.00–900.00 kg. ExoticRx lists 1 cited dose rule for Tildipirosin (Long-Acting) in cattle, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Zuprevo
| Route | Dose | Frequency | Indication | Evidence | Source |
|---|---|---|---|---|---|
| SC | 4 mg/kg | single dose | Bovine respiratory disease | Strong | Zuprevo(R) (Tildipirosin 18%) [Product Label]. Merck Animal Health; 2011. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1263 (2026-08-01). |
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16-membered ring macrolide that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit. Concentrates extensively in lung tissue.
SC injection in the posterior aspect of the ear only in cattle. Fatal if injected IV. Not for use in female dairy cattle 20 months of age or older.
Species-specific contraindications and adverse-reaction reports for cattle may differ from canine / feline reference data — consult the primary citations listed with each rule.
Tildipirosin (Long-Acting) dose range in cattle, with cited source references: SC 4 mg/kg single dose. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Tildipirosin (Long-Acting) in cattle: SC.
Tildipirosin (Long-Acting) is indicated in cattle for: Bovine respiratory disease.
These are general warnings for Tildipirosin (Long-Acting) across species; consult the cattle dosing table above for species-specific guidance. SC injection in the posterior aspect of the ear only in cattle. Fatal if injected IV. Not for use in female dairy cattle 20 months of age or older.
Why a species-specific page? Tildipirosin (Long-Acting) pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in cattle — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.