ExoticRx · exoticrx.com/drugs/topotecan
US brand names:Hycamtin
Topotecan is dosed at 0.75–1 mg/kg IV IV over 30 min q24h x 5d, q21d cycles in dogs, per Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed. Verify against current literature before clinical use.
Semi-synthetic camptothecin analogue that inhibits topoisomerase I by stabilizing the enzyme-DNA complex, preventing DNA religation and causing lethal double-strand breaks.
Severe myelosuppression is dose-limiting. Monitor CBC closely. Dose-reduce in renal impairment. Used investigationally for lymphoma and solid tumors in dogs.
Species references:All Dog (Domestic) drugs
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A dog/cat sample is shown here. Cited dosing for all 1 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IV | 0.75–1 mg/kg | IV over 30 min q24h x 5d, q21d cycles | Weak | Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.