ExoticRx · exoticrx.com/drugs/trabectedin
US brand names:Yondelis
Binds to minor groove of DNA, bending the helix toward the major groove. Interferes with transcription-coupled nucleotide excision repair and modulates tumor microenvironment.
Hepatotoxicity — monitor liver enzymes. Myelosuppression. Requires central venous access. Very limited veterinary data — investigational for soft tissue sarcomas.
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.