ExoticRx · exoticrx.com/drugs/trientine
US brand names:Syprine
Trientine is dosed at 10–15 mg/kg PO q12h in dogs, per Twedt D. Canine chronic hepatitis. WVC; 2012. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1302 (2026-08-01).. Verify against current literature before clinical use.
Chelates copper by forming a stable complex excreted in urine. Alternative to penicillamine for copper storage disease.
Less toxic than penicillamine. Give on empty stomach. May cause iron deficiency with chronic use.
Species references:All Dog (Domestic) drugs
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| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 10–15 mg/kg | q12h | Moderate | Twedt D. Canine chronic hepatitis. WVC; 2012. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1302 (2026-08-01). |
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