Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Trientine is dosed at 10–15 mg/kg PO q12h in dogs, per Twedt D. Canine chronic hepatitis. WVC; 2012. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1302 (2026-08-01). — Plumb's 10th ed (held) printed p.1274, Trientine monograph; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Trientine is used in dogs for Copper storage hepatopathy (penicillamine-intolerant). Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Trientine in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Syprine
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 10–15 mg/kg | q12h | Long-term; monitor hepatic copper levels | Copper storage hepatopathy (penicillamine-intolerant) | Moderate | Twedt D. Canine chronic hepatitis. WVC; 2012. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1302 (2026-08-01). — Plumb's 10th ed (held) printed p.1274, Trientine monograph; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 10–15 | PO | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.432 | 10-15 mg/kg p.o. q12h. Vomiting may be reduced by giving in divided doses with food. |
| 10–15 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.838 | • 10-15 mg/kg q12h PO 1-2 hours before feeding. |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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Chelates copper by forming a stable complex excreted in urine. Alternative to penicillamine for copper storage disease.
Less toxic than penicillamine. Give on empty stomach. May cause iron deficiency with chronic use.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Trientine dose range in dogs, with cited source references: PO 10–15 mg/kg q12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Trientine in dogs: PO.
Cited course lengths for Trientine in dogs include: Long-term; monitor hepatic copper levels. Duration depends on the indication — match it to the specific dose rule in the table above.
Trientine is indicated in dogs for: Copper storage hepatopathy (penicillamine-intolerant).
These are general warnings for Trientine across species; consult the dog dosing table above for species-specific guidance. Less toxic than penicillamine. Give on empty stomach. May cause iron deficiency with chronic use.
Why a species-specific page? Trientine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.