Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Trientine is dosed at 10–15 mg/kg PO q12h in dogs, per Twedt D. Canine chronic hepatitis. WVC; 2012. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1302 (2026-08-01).. Trientine is used in dogs for Copper storage hepatopathy (penicillamine-intolerant). Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Trientine in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Syprine
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 10–15 mg/kg | q12h | Long-term; monitor hepatic copper levels | Copper storage hepatopathy (penicillamine-intolerant) | Moderate | Twedt D. Canine chronic hepatitis. WVC; 2012. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1302 (2026-08-01). |
Need the exact dose for your patient?
These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Chelates copper by forming a stable complex excreted in urine. Alternative to penicillamine for copper storage disease.
Less toxic than penicillamine. Give on empty stomach. May cause iron deficiency with chronic use.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Trientine dose range in dogs, with cited source references: PO 10–15 mg/kg q12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Trientine in dogs: PO.
Cited course lengths for Trientine in dogs include: Long-term; monitor hepatic copper levels. Duration depends on the indication — match it to the specific dose rule in the table above.
Trientine is indicated in dogs for: Copper storage hepatopathy (penicillamine-intolerant).
These are general warnings for Trientine across species; consult the dog dosing table above for species-specific guidance. Less toxic than penicillamine. Give on empty stomach. May cause iron deficiency with chronic use.
Why a species-specific page? Trientine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.