Busulfan for Cat
Cat · Felis catus · typical adult weight 2.50–7.00 kg
Busulfan is used in cat for Polycythemia vera. Routes documented in cat: PO. A typical adult cat weighs 2.50–7.00 kg. ExoticRx lists 1 cited dose rule for Busulfan in cat, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Myleran, Busulfex
Dose ranges
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 2–4 mg/kg | PO q24h until remission | Until PCV normalizes; intermittent maintenance | Polycythemia vera | Weak | Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed |
Need the exact dose for your patient?
These ranges are per kg. Enter your cat's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Mechanism of action
Bifunctional alkylating agent that cross-links DNA strands, interfering with DNA replication and transcription. Preferentially affects granulocyte precursors.
Side effects & warnings
Severe myelosuppression — monitor CBC closely. Pulmonary fibrosis with chronic use. Hepatotoxicity (sinusoidal obstruction syndrome). Limited veterinary use for polycythemia vera and CML.
Species-specific contraindications and adverse-reaction reports for cat may differ from canine / feline reference data — consult the primary citations listed with each rule.
Other Oncology drugs with cat dosing
Busulfan dosing in other species
Why a species-specific page? Busulfan pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in cat — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.