ExoticRx · exoticrx.com/drugs/cyproheptadine
US brand names:Periactin
Also known as: Cyproheptadine (Respiratory)
Cyproheptadine is dosed at 1–4 mg/rabbit (total dose, NOT mg/kg) PO q12-24h in rabbits, per Graham JE. Personal observation; 2020. — Source: Carpenter's Exotic Animal Formulary, 6th Ed, p.877. Verify against current literature before clinical use.
Piperidine antihistamine with potent 5-HT2A serotonin receptor antagonism and H1 blockade, providing both antiallergic and antiserotonergic effects. Also acts as bronchodilator.
Appetite stimulation is a prominent effect. Sedation possible. Used for feline asthma as bronchodilator adjunct and serotonin syndrome antidote.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugsAll Ferret drugsAll Guinea Pig drugsAll Rabbit (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 5 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Cat (Domestic) | PO | 1–4 mg per cat | q12h | Moderate | Agnew W, Korman R. Pharmacological appetite stimulation: rational choices in the inappetent cat. J Feline Med Surg. 2014;16(9):749-756.; Webb CB. Hepatic lipidosis: Clinical review drawn from collective effort. J Feline Med Surg. 2018;20(3):217-227. doi:10.1177/1098612x18758591 — Plumb's 10th ed printed p.327, Cyproheptadine monograph spanning p.327-328. |
| Dog (Domestic) | PO | 0.3–2 mg/kg | q8-12h | Moderate | Plumb's Veterinary Drug Handbook, 10th ed (2023) — Plumb's 10th ed printed p.327, Cyproheptadine monograph spanning p.327-328.Compilation only — we have not located an independent source that prints this figure. |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.