ExoticRx · exoticrx.com/drugs/enalapril
US brand names:Enacard, Vasotec
Enalapril is dosed at 0.5 mg/kg PO q48 h in veiled chameleons, per Congestive heart failure in a veiled chameleon (Chamaeleo calyptratus): A case report. DOI 10.17221/67/2021-VETMED; PMID 39170907; PMCID PMC11334147. https://pmc.ncbi.nlm.nih.gov/articles/PMC11334147/ URL: https://pmc.ncbi.nlm.nih.gov/articles/PMC11334147/. Verify against current literature before clinical use.
Prodrug converted to enalaprilat, which inhibits ACE. Reduces angiotensin II, decreases aldosterone, reduces preload and afterload.
Monitor renal function (BUN/creatinine) and electrolytes. Hypotension with concurrent diuretics. Primarily renal elimination (prefer benazepril in renal disease). CONTRAINDICATED in pregnancy.
Species references:All African Pygmy Hedgehog drugsAll Amazon Parrot drugsAll Cat (Domestic) drugsAll Dog (Domestic) drugsAll Ferret drugsAll Lovebird drugsAll Sugar Glider drugsAll Veiled Chameleon drugs
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A dog/cat sample is shown here. Cited dosing for all 8 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 0.5 mg/kg | q12-24h | Strong | Enacard Tablets for Dogs [UK Datasheet]. Merial Limited; 2006. | Keene BW, Atkins CE, Bonagura JD, et al. ACVIM consensus guidelines for the diagnosis and treatment of myxomatous mitral valve disease in dogs. J Vet Intern Med. 2019;33(3):1127-1140. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.474 (2026-08-01). — Plumb's 10th ed (held) printed p.447, Enalapril monograph spanning p.445-447; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
| Cat (Domestic) | PO | 0.25–0.5 mg/kg | q12-24h | Moderate | Treatment Recommendations for CKD in Dogs. International Renal Interest Society; 2019. | Polzin DJ. Evidence-based step-wise approach to managing chronic kidney disease in dogs and cats. J Vet Emerg Crit Care. 2013;23(2):205-215. | Bartges JW. Chronic kidney disease in dogs and cats. Vet Clin North Am Small Animal Pract. 2012;42(4):669-692. | Littman MP. Protein-losing nephropathy in small animals. Vet Clin North Am Small Animal Pract. 2011;41(1):31-62. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.474 (2026-08-01). — Plumb's 10th ed (held) printed p.447, Enalapril monograph spanning p.445-447; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, |
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