Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Epoprostenol is dosed at 1–5 ng/kg/min IV Continuous IV infusion in dogs, per Corroborated 2026-07-31: Yuchi Y, Suzuki R, Satomi S, et al. Vet Sci 2023;10(4):302. doi:10.3390/vetsci10040302 PMID:37104457 - dog, epoprostenol IV infusion 2-20 ng/kg/min in 6 beagles with experimental chronic pulmonary hypertension; PVR fell at 15-20 ng/kg/min.. Epoprostenol is used in dogs for Severe pulmonary hypertension. Routes documented in dogs: IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Epoprostenol in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Flolan, Veletri
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 1–5 ng/kg/min | Continuous IV infusion | Short-term; cannot be safely administered long-term in veterinary patients | Severe pulmonary hypertension |
| Corroborated 2026-07-31: Yuchi Y, Suzuki R, Satomi S, et al. Vet Sci 2023;10(4):302. doi:10.3390/vetsci10040302 PMID:37104457 - dog, epoprostenol IV infusion 2-20 ng/kg/min in 6 beagles with experimental chronic pulmonary hypertension; PVR fell at 15-20 ng/kg/min. |
One of the cited rules is a continuous-rate-infusion regimen: IV 1–5 ng/kg/min Continuous IV infusion. CRI regimens are delivered as a continuous infusion rather than discrete doses — verify the rate against the cited source before use.
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Synthetic prostacyclin (PGI2) that causes potent pulmonary and systemic vasodilation and inhibits platelet aggregation via cAMP elevation.
Continuous IV infusion required — very short half-life (~6 min). Abrupt discontinuation can cause fatal rebound PH. Hypotension risk.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Epoprostenol dose range in dogs, with cited source references: IV 1–5 ng/kg/min Continuous IV infusion. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Epoprostenol in dogs: IV.
Cited course lengths for Epoprostenol in dogs include: Short-term; cannot be safely administered long-term in veterinary patients. Duration depends on the indication — match it to the specific dose rule in the table above.
Epoprostenol is indicated in dogs for: Severe pulmonary hypertension.
These are general warnings for Epoprostenol across species; consult the dog dosing table above for species-specific guidance. Continuous IV infusion required — very short half-life (~6 min). Abrupt discontinuation can cause fatal rebound PH. Hypotension risk.
Why a species-specific page? Epoprostenol pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.