Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Epoprostenol is dosed at 1–5 ng/kg/min IV Continuous IV infusion in dogs, per Corroborated 2026-07-31: Yuchi Y, Suzuki R, Satomi S, et al. Vet Sci 2023;10(4):302. doi:10.3390/vetsci10040302 PMID:37104457 - dog, epoprostenol IV infusion 2-20 ng/kg/min in 6 beagles with experimental chronic pulmonary hypertension; PVR fell at 15-20 ng/kg/min.. Epoprostenol is used in dogs for Severe pulmonary hypertension. Routes documented in dogs: IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Epoprostenol in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Flolan, Veletri
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 1–5 ng/kg/min | Continuous IV infusion | Short-term; cannot be safely administered long-term in veterinary patients | Severe pulmonary hypertension | Weak | Corroborated 2026-07-31: Yuchi Y, Suzuki R, Satomi S, et al. Vet Sci 2023;10(4):302. doi:10.3390/vetsci10040302 PMID:37104457 - dog, epoprostenol IV infusion 2-20 ng/kg/min in 6 beagles with experimental chronic pulmonary hypertension; PVR fell at 15-20 ng/kg/min. |
One of the cited rules is a continuous-rate-infusion regimen: IV 1–5 ng/kg/min Continuous IV infusion. CRI regimens are delivered as a continuous infusion rather than discrete doses — verify the rate against the cited source before use.
Need the exact dose for your patient?
These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Synthetic prostacyclin (PGI2) that causes potent pulmonary and systemic vasodilation and inhibits platelet aggregation via cAMP elevation.
Continuous IV infusion required — very short half-life (~6 min). Abrupt discontinuation can cause fatal rebound PH. Hypotension risk.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Epoprostenol dose range in dogs, with cited source references: IV 1–5 ng/kg/min Continuous IV infusion. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Epoprostenol in dogs: IV.
Cited course lengths for Epoprostenol in dogs include: Short-term; cannot be safely administered long-term in veterinary patients. Duration depends on the indication — match it to the specific dose rule in the table above.
Epoprostenol is indicated in dogs for: Severe pulmonary hypertension.
These are general warnings for Epoprostenol across species; consult the dog dosing table above for species-specific guidance. Continuous IV infusion required — very short half-life (~6 min). Abrupt discontinuation can cause fatal rebound PH. Hypotension risk.
Why a species-specific page? Epoprostenol pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.