Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Famotidine is dosed at 0.5–1 mg/kg IV q12h in dogs, per Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.527 (2026-08-01).. Famotidine is used in dogs for Acute GI ulceration, stress gastritis, Renal failure gastric protection, Mast cell tumor gastric protection, Stress gastritis prevention. Routes documented in dogs: IV, PO, SC. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 6 cited dose rules for Famotidine in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Pepcid
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 0.5–1 mg/kg | q12h | Until oral feasible | Acute GI ulceration, stress gastritis | Strong | Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.527 (2026-08-01). |
| IV | 0.5–1 mg/kg | q12h | During hospitalization for AKI/CKD crisis | Renal failure gastric protection | Strong | Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.527 (2026-08-01). |
| PO | 1–2 mg/kg | q12h | During MCT treatment | Mast cell tumor gastric protection | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed |
| PO | 0.5–1 mg/kg | q12h | During hospitalization | Stress gastritis prevention | Moderate | Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.527 (2026-08-01). |
| PO | 0.5–1 mg/kg | q12-24h | 5-14 days or as needed | Gastric acid reduction, GI ulceration prevention | Strong | Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.527 (2026-08-01). |
| SC | 0.5–1 mg/kg | q12-24h | As needed | Gastric acid reduction | Strong | Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.527 (2026-08-01). |
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Competitively blocks histamine H2 receptors on parietal cells, reducing basal and stimulated gastric acid secretion.
Generally well-tolerated. Adjust dose in renal impairment. Less effective than proton pump inhibitors at acid suppression.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Famotidine dose ranges in dogs, with cited source references: IV 0.5–1 mg/kg q12h; IV 0.5–1 mg/kg q12h; PO 1–2 mg/kg q12h; PO 0.5–1 mg/kg q12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Famotidine in dogs: IV, PO, SC.
Cited course lengths for Famotidine in dogs include: Until oral feasible; During hospitalization for AKI/CKD crisis; During MCT treatment; During hospitalization. Duration depends on the indication — match it to the specific dose rule in the table above.
Famotidine is indicated in dogs for: Acute GI ulceration, stress gastritis, Renal failure gastric protection, Mast cell tumor gastric protection, Stress gastritis prevention, Gastric acid reduction, GI ulceration prevention, Gastric acid reduction.
These are general warnings for Famotidine across species; consult the dog dosing table above for species-specific guidance. Generally well-tolerated. Adjust dose in renal impairment. Less effective than proton pump inhibitors at acid suppression.
Why a species-specific page? Famotidine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.