Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Linaclotide is dosed at 0.003–0.01 mg/kg PO q24h in dogs, per Source not established. The citation previously shown here named no retrievable document; a literature search on 2026-07-31 found no source that states this dose for this species and route. Treat as unverified and confirm against a primary reference before clinical use.. Linaclotide is used in dogs for Chronic constipation. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Linaclotide in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Linzess
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 0.003–0.01 mg/kg | q24h | Investigational; no established veterinary dose | Chronic constipation | Extrapolated | Source not established. The citation previously shown here named no retrievable document; a literature search on 2026-07-31 found no source that states this dose for this species and route. Treat as unverified and confirm against a primary reference before clinical use. |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Guanylate cyclase-C agonist that increases cyclic GMP, stimulating intestinal chloride and bicarbonate secretion, accelerating transit and reducing visceral pain.
Diarrhea is most common side effect. Not absorbed systemically. Minimal veterinary data — experimental use only.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Linaclotide dose range in dogs, with cited source references: PO 0.003–0.01 mg/kg q24h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Linaclotide in dogs: PO.
Cited course lengths for Linaclotide in dogs include: Investigational; no established veterinary dose. Duration depends on the indication — match it to the specific dose rule in the table above.
Linaclotide is indicated in dogs for: Chronic constipation.
These are general warnings for Linaclotide across species; consult the dog dosing table above for species-specific guidance. Diarrhea is most common side effect. Not absorbed systemically. Minimal veterinary data — experimental use only.
Why a species-specific page? Linaclotide pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.