Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Lubiprostone is dosed at 3–6 mcg/kg PO q12h in dogs, per Plumb's Veterinary Drug Handbook, 9th Ed. Lubiprostone is used in dogs for Chronic constipation. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Lubiprostone in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Amitiza
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 3–6 mcg/kg | q12h | Variable | Chronic constipation | Weak | Plumb's Veterinary Drug Handbook, 9th Ed |
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Activates type 2 chloride channels (ClC-2) in intestinal epithelium, increasing intestinal fluid secretion and promoting motility.
Used for chronic constipation. Nausea common. Limited veterinary data. Take with food. Contraindicated with mechanical GI obstruction.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Lubiprostone dose range in dogs, with cited source references: PO 3–6 mcg/kg q12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Lubiprostone in dogs: PO.
Cited course lengths for Lubiprostone in dogs include: Variable. Duration depends on the indication — match it to the specific dose rule in the table above.
Lubiprostone is indicated in dogs for: Chronic constipation.
These are general warnings for Lubiprostone across species; consult the dog dosing table above for species-specific guidance. Used for chronic constipation. Nausea common. Limited veterinary data. Take with food. Contraindicated with mechanical GI obstruction.
Why a species-specific page? Lubiprostone pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.