ExoticRx · exoticrx.com/drugs/mavacoxib
US brand names:Trocoxil
Mavacoxib is dosed at 2 mg/kg PO Day 0, Day 14, then monthly (max 7 doses) in dogs, per Cox SR, Lesman SP, Boucher JF et al. (2010) The pharmacokinetics of mavacoxib, a long-acting COX-2 inhibitor, in young adult laboratory dogs. Journal of Veterinary Pharmacology and Therapeutics 33, 461-470 | Cox SR, Liao S, Payne-Johnson M et al. (2011) Population pharmacokinetics of mavacoxib in osteoarthritic dogs. Journal of Veterinary Pharmaology and Therapeutics 34, 1-11 doi:10.1111/j.1365-2885.2010.01165.x — Verified against BSAVA Small Animal Formulary, 10th Ed, Part A, p.263 (2026-08-01).. Verify against current literature before clinical use.
Selective COX-2 inhibitor with extremely long half-life (44 days in dogs). Once-monthly dosing after initial loading.
Dogs only (EU-approved). Very long half-life — cannot rapidly discontinue if adverse effects. Not for dogs <12 months or <5kg. Monitor hepatic/renal. Maximum 7 doses (6.5 months).
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 2 mg/kg | Day 0, Day 14, then monthly (max 7 doses) | Strong | Cox SR, Lesman SP, Boucher JF et al. (2010) The pharmacokinetics of mavacoxib, a long-acting COX-2 inhibitor, in young adult laboratory dogs. Journal of Veterinary Pharmacology and Therapeutics 33, 461-470 | Cox SR, Liao S, Payne-Johnson M et al. (2011) Population pharmacokinetics of mavacoxib in osteoarthritic dogs. Journal of Veterinary Pharmaology and Therapeutics 34, 1-11 doi:10.1111/j.1365-2885.2010.01165.x — Verified against BSAVA Small Animal Formulary, 10th Ed, Part A, p.263 (2026-08-01). |
| Cat (Domestic) | PO | Dogs only | N/A | Extrapolated | Verified against BSAVA Small Animal Formulary, 10th Ed, Part A, p.263 (2026-08-01). |
Upgrade to Pro or Student to unlock the full dose ranges and frequency for every species. The drug's mechanism, warnings, indications, and cited sources are free to read.
View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.