ExoticRx · exoticrx.com/drugs/mavacoxib
US brand names:Trocoxil
Mavacoxib is dosed at 4 mg/kg PO single dose in cockatiels, per Dhondt L, Devreese M, Croubels S, De Baere S, Haesendonck R, Goessens T, Gehring R, De Backer P, Antonissen G. Comparative population pharmacokinetics and absolute oral bioavailability of COX-2 selective inhibitors celecoxib, mavacoxib and meloxicam in cockatiels (Nymphicus hollandicus). Sci Rep. 2017;7(1):12043. Verify against current literature before clinical use.
Selective COX-2 inhibitor with extremely long half-life (44 days in dogs). Once-monthly dosing after initial loading.
Dogs only (EU-approved). Very long half-life — cannot rapidly discontinue if adverse effects. Not for dogs <12 months or <5kg. Monitor hepatic/renal. Maximum 7 doses (6.5 months).
Species references:All Cat (Domestic) drugsAll Cockatiel drugsAll Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
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| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 2 mg/kg | Day 0, Day 14, then monthly (max 7 doses) | Strong | Cox SR, Lesman SP, Boucher JF et al. (2010) The pharmacokinetics of mavacoxib, a long-acting COX-2 inhibitor, in young adult laboratory dogs. Journal of Veterinary Pharmacology and Therapeutics 33, 461-470 | Cox SR, Liao S, Payne-Johnson M et al. (2011) Population pharmacokinetics of mavacoxib in osteoarthritic dogs. Journal of Veterinary Pharmaology and Therapeutics 34, 1-11 doi:10.1111/j.1365-2885.2010.01165.x — BSAVA Small Animal Formulary, 10th Ed, Part A, p.247 |
| Cat (Domestic) | PO | See the cited source for the printed regimen | N/A | Extrapolated | BSAVA Small Animal Formulary, 10th Ed, Part A, p.247Compilation only — we have not located an independent source that prints this figure. |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.