Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Nitroprusside is used in dog for Acute severe heart failure, hypertensive crisis. Routes documented in dog: IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Nitroprusside in dog, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Nipride
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 1–5 mcg/kg/min | CRI (continuous rate infusion) | Until stabilized | Acute severe heart failure, hypertensive crisis | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed |
One of the cited rules is a continuous-rate-infusion regimen: IV 1–5 mcg/kg/min CRI (continuous rate infusion). CRI regimens are delivered as a continuous infusion rather than discrete doses — verify the rate against the cited source before use.
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Releases nitric oxide, activating guanylyl cyclase in vascular smooth muscle, causing vasodilation of both arteries and veins.
ICU drug — continuous IV infusion with arterial blood pressure monitoring required. Cyanide toxicity risk with prolonged use (>48h). Light-sensitive — wrap in foil. Immediate onset, very short duration.
Species-specific contraindications and adverse-reaction reports for dog may differ from canine / feline reference data — consult the primary citations listed with each rule.
Why a species-specific page? Nitroprusside pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dog — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.