Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Omeprazole is used in dog for Gastric ulceration, esophagitis, GERD, NSAID-induced gastropathy prevention, Mast cell tumor adjunct (gastric protection), Helicobacter gastritis. Routes documented in dog: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 4 cited dose rules for Omeprazole in dog, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Prilosec, GastroGard
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 0.5–1.5 mg/kg | q12-24h | 14-28 days | Gastric ulceration, esophagitis, GERD | Strong | Plumb's Veterinary Drug Handbook, 9th Ed |
| PO | 0.5–1 mg/kg | q24h | During NSAID therapy | NSAID-induced gastropathy prevention | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed |
| PO | 1–1.5 mg/kg | q12h | During MCT treatment | Mast cell tumor adjunct (gastric protection) | Strong | Plumb's Veterinary Drug Handbook, 9th Ed |
| PO | 1–1.5 mg/kg | q12h | 14-21 days (with antibiotics) | Helicobacter gastritis | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Irreversibly inhibits H+/K+-ATPase (proton pump) on parietal cells, providing potent and prolonged gastric acid suppression.
Must not be crushed (enteric-coated). Takes 3-5 days for full effect. Long-term use may affect calcium/magnesium absorption. Interacts with drugs requiring acid pH for absorption.
Species-specific contraindications and adverse-reaction reports for dog may differ from canine / feline reference data — consult the primary citations listed with each rule.
Why a species-specific page? Omeprazole pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dog — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.