Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Omeprazole is dosed at 0.5–1.5 mg/kg PO q12-24h in dogs, per Bersenas AM, Mathews KA, Allen DG and Conlon PD (2005) Effects of ranitidine, famotidine, pantoprazole, and omeprazole on intragastric pH in dogs. American Journal of Veterinary Research 66, 425-431 — BSAVA Small Animal Formulary, 10th Ed, Part A, p.292. Omeprazole is used in dogs for Gastric ulceration, esophagitis, GERD, Mast cell tumor adjunct (gastric protection), Helicobacter gastritis, NSAID-induced gastropathy prevention. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 4 cited dose rules for Omeprazole in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Prilosec, GastroGard
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 0.5–1.5 mg/kg | q12-24h | 14-28 days | Gastric ulceration, esophagitis, GERD | Strong | Bersenas AM, Mathews KA, Allen DG and Conlon PD (2005) Effects of ranitidine, famotidine, pantoprazole, and omeprazole on intragastric pH in dogs. American Journal of Veterinary Research 66, 425-431 — BSAVA Small Animal Formulary, 10th Ed, Part A, p.292 |
| PO | 1–1.5 mg/kg | q12h | During MCT treatment | Mast cell tumor adjunct (gastric protection) | Strong | Marks SL. Chapter 273: Diseases of the Pharynx and Esophagus. In: Ettinger SJ, Feldman EC, Cote E, eds. Textbook of Veterinary Internal Medicine. Vol 2. Elsevier Health Sciences; 2017:1476-1490. — Plumb's 10th ed printed p.953, Omeprazole monograph spanning p.953-955.Compilation only — we have not located an independent source that prints this figure. |
| PO | 0.5–1 mg/kg | q12h | 14-21 days (with antibiotics) | Helicobacter gastritis | Moderate | Marks SL. Chapter 273: Diseases of the Pharynx and Esophagus. In: Ettinger SJ, Feldman EC, Cote E, eds. Textbook of Veterinary Internal Medicine. Vol 2. Elsevier Health Sciences; 2017:1476-1490. — Plumb's 10th ed printed p.953, Omeprazole monograph spanning p.953-955.Compilation only — we have not located an independent source that prints this figure. |
| PO | 0.5–1 mg/kg | q24h | During NSAID therapy | NSAID-induced gastropathy prevention | Moderate | Mirzaeian S, Sarchahi AA, Tabrizi AS, Derakhshandeh A. Eradication of gastric Helicobacter spp. by triple therapy in dogs. Veterinarni Medicina. 2013;58:582-586. PMID: 23558958 — Plumb's 10th ed printed p.953, Omeprazole monograph spanning p.953-955. |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 0.5–1.5 | IV | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.308 | 0.5-1.5 mg/kg i.v., p.o. q12-24h for a maximum of 8 weeks |
| 1–2 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.607 | • 20 mg per dog q24h PO or 1-2 mg/kg • 1 mg/kg q24h PO. |
| 1 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.607 | • 20 mg per dog q24h PO or 1-2 mg/kg • 1 mg/kg q24h PO. |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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Irreversibly inhibits H+/K+-ATPase (proton pump) on parietal cells, providing potent and prolonged gastric acid suppression.
Must not be crushed (enteric-coated). Takes 3-5 days for full effect. Long-term use may affect calcium/magnesium absorption. Interacts with drugs requiring acid pH for absorption.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Omeprazole dose ranges in dogs, with cited source references: PO 0.5–1.5 mg/kg q12-24h; PO 1–1.5 mg/kg q12h; PO 0.5–1 mg/kg q12h; PO 0.5–1 mg/kg q24h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Omeprazole in dogs: PO.
Cited course lengths for Omeprazole in dogs include: 14-28 days; During MCT treatment; 14-21 days (with antibiotics); During NSAID therapy. Duration depends on the indication — match it to the specific dose rule in the table above.
Omeprazole is indicated in dogs for: Gastric ulceration, esophagitis, GERD, Mast cell tumor adjunct (gastric protection), Helicobacter gastritis, NSAID-induced gastropathy prevention.
These are general warnings for Omeprazole across species; consult the dog dosing table above for species-specific guidance. Must not be crushed (enteric-coated). Takes 3-5 days for full effect. Long-term use may affect calcium/magnesium absorption. Interacts with drugs requiring acid pH for absorption.
Why a species-specific page? Omeprazole pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.