Cat · Felis catus · typical adult weight 2.50–7.00 kg
Pemetrexed is used in cat for Mesothelioma (investigational). Routes documented in cat: IV. A typical adult cat weighs 2.50–7.00 kg. ExoticRx lists 1 cited dose rule for Pemetrexed in cat, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Alimta
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 200–300 mg/kg | 200-300mg/m2 IV q21 days | Vitamin supplementation required | Mesothelioma (investigational) | Anecdotal | Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed |
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These ranges are per kg. Enter your cat's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Inhibits multiple folate-dependent enzymes: thymidylate synthase, dihydrofolate reductase, and glycinamide ribonucleotide formyltransferase. Disrupts both purine and pyrimidine synthesis.
Requires folic acid and vitamin B12 supplementation to reduce toxicity. Myelosuppression, skin rash. Renal dosing required. Very limited veterinary data.
Species-specific contraindications and adverse-reaction reports for cat may differ from canine / feline reference data — consult the primary citations listed with each rule.
Why a species-specific page? Pemetrexed pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in cat — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.