Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Pemetrexed is used in dog for Mesothelioma / carcinomas (investigational). Routes documented in dog: IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Pemetrexed in dog, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Alimta
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 300–500 mg/kg | 300-500mg/m2 IV over 10 min q21 days | Supplement folic acid and vitamin B12 | Mesothelioma / carcinomas (investigational) | Anecdotal | Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Inhibits multiple folate-dependent enzymes: thymidylate synthase, dihydrofolate reductase, and glycinamide ribonucleotide formyltransferase. Disrupts both purine and pyrimidine synthesis.
Requires folic acid and vitamin B12 supplementation to reduce toxicity. Myelosuppression, skin rash. Renal dosing required. Very limited veterinary data.
Species-specific contraindications and adverse-reaction reports for dog may differ from canine / feline reference data — consult the primary citations listed with each rule.
Why a species-specific page? Pemetrexed pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dog — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.