Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Dactinomycin is used in dog for Lymphoma / soft tissue sarcoma, Wilms tumor / embryonal tumors (investigational). Routes documented in dog: IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 2 cited dose rules for Dactinomycin in dog, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Cosmegen
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 0.5–0.7 mg/kg | 0.5-0.7mg/m2 IV q21 days | Severe vesicant — verify IV placement before infusion | Lymphoma / soft tissue sarcoma | Weak | Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed |
| IV | 0.5–0.7 mg/kg | 0.5-0.7mg/m2 IV q14-21 days | Part of combination protocol; monitor CBC nadir | Wilms tumor / embryonal tumors (investigational) | Anecdotal | Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Intercalates into DNA between guanine-cytosine base pairs, blocking RNA polymerase and inhibiting transcription. Also causes topoisomerase II-mediated DNA breaks.
Severe vesicant — extravasation causes tissue necrosis. Potent myelosuppression and GI toxicity. Radiosensitizer — avoid concurrent radiation. Very limited veterinary use.
Species-specific contraindications and adverse-reaction reports for dog may differ from canine / feline reference data — consult the primary citations listed with each rule.
Why a species-specific page? Dactinomycin pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dog — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.