Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Cladribine is used in dog for Low-grade lymphocytic lymphoma / CLL, CLL / low-grade lymphoma (subcutaneous protocol). Routes documented in dog: IV, SC. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 2 cited dose rules for Cladribine in dog, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Leustatin
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 0.1–0.14 mg/kg | IV CRI over 2h q24h x 5 days per cycle | Monitor CBC — profound lymphopenia expected | Low-grade lymphocytic lymphoma / CLL | Weak | Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed |
| SC | 0.1–0.14 mg/kg | 0.1-0.14mg/kg SC q24h x 5 days per cycle | Monitor CBC weekly after each cycle | CLL / low-grade lymphoma (subcutaneous protocol) | Weak | Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed |
One of the cited rules is a continuous-rate-infusion regimen: IV 0.1–0.14 mg/kg IV CRI over 2h q24h x 5 days per cycle. CRI regimens are delivered as a continuous infusion rather than discrete doses — verify the rate against the cited source before use.
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Adenosine deaminase-resistant purine nucleoside analogue. Phosphorylated intracellularly to active triphosphate form that incorporates into DNA, causing strand breaks and apoptosis.
Profound lymphopenia — immunosuppression lasting months. Myelosuppression. Fever common. Used investigationally for lymphocytic leukemia and low-grade lymphoma in dogs.
Species-specific contraindications and adverse-reaction reports for dog may differ from canine / feline reference data — consult the primary citations listed with each rule.
Why a species-specific page? Cladribine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dog — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.