ExoticRx · exoticrx.com/drugs/pentoxifylline-respiratory
US brand names:Trental
Pentoxifylline (Respiratory) is dosed at 10–25 mg/kg PO q8-12h in dogs, per Koch S, Torres S, Plumb D. Small Animal Dermatology Drug Handbook. Wiley-Blackwell; 2012. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1030 (2026-08-01).. Verify against current literature before clinical use.
Non-selective phosphodiesterase inhibitor that improves red blood cell deformability, reduces blood viscosity, and inhibits TNF-alpha and neutrophil activation in pulmonary vasculature.
GI upset at initiation. Used for pulmonary fibrosis and chronic bronchitis adjunct therapy. Anti-inflammatory effects complement bronchodilators.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 10–25 mg/kg | q8-12h | Moderate | Koch S, Torres S, Plumb D. Small Animal Dermatology Drug Handbook. Wiley-Blackwell; 2012. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1030 (2026-08-01). |
| Cat (Domestic) | PO | 10–25 mg/kg | q8-12h | Weak | Plumb's Veterinary Drug Handbook, 9th Ed |
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