ExoticRx · exoticrx.com/drugs/pentoxifylline
US brand names:Trental
Pentoxifylline is dosed at 15–25 mg/kg PO q12h in dogs, per Hillier A. Why Are These Nails Falling Off? Claw Diseases of the Dog. Presented at: Atlantic Coast Vet Conference; 2015. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1030 (2026-08-01).. Verify against current literature before clinical use.
Phosphodiesterase inhibitor improving red blood cell deformability and reducing blood viscosity. Also inhibits TNF-alpha and other cytokines.
Used for dermatomyositis, vasculitis, and microcirculatory disorders. GI upset common (give with food). Do not crush ER tablets. Generally well tolerated.
Species references:All Dog (Domestic) drugs
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| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 15–25 mg/kg | q12h | Moderate | Hillier A. Why Are These Nails Falling Off? Claw Diseases of the Dog. Presented at: Atlantic Coast Vet Conference; 2015. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1030 (2026-08-01). |
| Dog (Domestic) | PO | 10–25 mg/kg | q8-12h | Moderate | Koch S, Torres S, Plumb D. Small Animal Dermatology Drug Handbook. Wiley-Blackwell; 2012. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1030 (2026-08-01). |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.