Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Pentoxifylline is dosed at 15–25 mg/kg PO q12h in dogs, per Hillier A. Why Are These Nails Falling Off? Claw Diseases of the Dog. Presented at: Atlantic Coast Vet Conference; 2015. — Plumb's 10th ed printed p.1003, Pentoxifylline monograph spanning p.1002-1003. — Plumb's Veterinary Drug Handbook, 10th ed, Pentoxifylline monograph, printed p.1004, DOGS: "Ischemic dermatopathies (extra-label): 15 mg/kg PO every 8 hours to 30 mg/kg PO every 12 hours. One […]"; same monograph, printed p.1002, Uses/Indications: "It is also used for ischemic dermatopathies including familial canine dermatomyositis.". Pentoxifylline is used in dogs for Ischemic dermatopathy, including dermatomyositis (extra-label), Dermatomyositis, vasculitis. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 2 cited dose rules for Pentoxifylline in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Trental
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 15–25 mg/kg | q12h | Weeks to months | Ischemic dermatopathy, including dermatomyositis (extra-label) | Moderate |
| Hillier A. Why Are These Nails Falling Off? Claw Diseases of the Dog. Presented at: Atlantic Coast Vet Conference; 2015. — Plumb's 10th ed printed p.1003, Pentoxifylline monograph spanning p.1002-1003. — Plumb's Veterinary Drug Handbook, 10th ed, Pentoxifylline monograph, printed p.1004, DOGS: "Ischemic dermatopathies (extra-label): 15 mg/kg PO every 8 hours to 30 mg/kg PO every 12 hours. One […]"; same monograph, printed p.1002, Uses/Indications: "It is also used for ischemic dermatopathies including familial canine dermatomyositis."Compilation only — we have not located an independent source that prints this figure. |
| PO | 10–25 mg/kg | q8-12h | Weeks to months | Dermatomyositis, vasculitis | Moderate | Koch S, Torres S, Plumb D. Small Animal Dermatology Drug Handbook. Wiley-Blackwell; 2012. — Plumb's 10th ed printed p.1002, Pentoxifylline monograph spanning p.1002-1003.Compilation only — we have not located an independent source that prints this figure. |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
The sources disagree for this combination. The ranges below do not overlap on a comparable route. This is not an error in one of them — published veterinary references differ, and reconciling them for a particular patient is a clinical judgement.
| Dose (mg/animal) | Route | Source | As printed |
|---|---|---|---|
| 400 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.649 | • Other uses: 10-15 mg/kg q8 PO or 400 mg/dog for most animals. |
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 15 | — | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.328 | 15 mg/kg q8-12h |
| 10 | PO |
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Phosphodiesterase inhibitor improving red blood cell deformability and reducing blood viscosity. Also inhibits TNF-alpha and other cytokines.
Used for dermatomyositis, vasculitis, and microcirculatory disorders. GI upset common (give with food). Do not crush ER tablets. Generally well tolerated.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Pentoxifylline dose ranges in dogs, with cited source references: PO 15–25 mg/kg q12h; PO 10–25 mg/kg q8-12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Pentoxifylline in dogs: PO.
Cited course lengths for Pentoxifylline in dogs include: Weeks to months. Duration depends on the indication — match it to the specific dose rule in the table above.
Pentoxifylline is indicated in dogs for: Ischemic dermatopathy, including dermatomyositis (extra-label), Dermatomyositis, vasculitis.
These are general warnings for Pentoxifylline across species; consult the dog dosing table above for species-specific guidance. Used for dermatomyositis, vasculitis, and microcirculatory disorders. GI upset common (give with food). Do not crush ER tablets. Generally well tolerated.
Why a species-specific page? Pentoxifylline pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.
| Papich Saunders Handbook of Veterinary Drugs, 4th edp.649 |
| • Dermatologic use: 10 mg/kg q12h PO, up to 15 mg/kg q8h PO. |
| 15 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.649 | • Dermatologic use: 10 mg/kg q12h PO, up to 15 mg/kg q8h PO. |
| 25 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.649 | • Familial canine dermatomyositis: 25 mg/kg q12h PO. |
| 10–15 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.649 | • Other uses: 10-15 mg/kg q8 PO or 400 mg/dog for most animals. |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.