Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Pentoxifylline is dosed at 15–25 mg/kg PO q12h in dogs, per Hillier A. Why Are These Nails Falling Off? Claw Diseases of the Dog. Presented at: Atlantic Coast Vet Conference; 2015. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1030 (2026-08-01).. Pentoxifylline is used in dogs for Vasculitis, dermatomyositis, Dermatomyositis, vasculitis. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 2 cited dose rules for Pentoxifylline in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Trental
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 15–25 mg/kg | q12h | Weeks to months | Vasculitis, dermatomyositis | Moderate | Hillier A. Why Are These Nails Falling Off? Claw Diseases of the Dog. Presented at: Atlantic Coast Vet Conference; 2015. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1030 (2026-08-01). |
| PO | 10–25 mg/kg | q8-12h | Weeks to months | Dermatomyositis, vasculitis | Moderate | Koch S, Torres S, Plumb D. Small Animal Dermatology Drug Handbook. Wiley-Blackwell; 2012. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1030 (2026-08-01). |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Phosphodiesterase inhibitor improving red blood cell deformability and reducing blood viscosity. Also inhibits TNF-alpha and other cytokines.
Used for dermatomyositis, vasculitis, and microcirculatory disorders. GI upset common (give with food). Do not crush ER tablets. Generally well tolerated.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Pentoxifylline dose ranges in dogs, with cited source references: PO 15–25 mg/kg q12h; PO 10–25 mg/kg q8-12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Pentoxifylline in dogs: PO.
Cited course lengths for Pentoxifylline in dogs include: Weeks to months. Duration depends on the indication — match it to the specific dose rule in the table above.
Pentoxifylline is indicated in dogs for: Vasculitis, dermatomyositis, Dermatomyositis, vasculitis.
These are general warnings for Pentoxifylline across species; consult the dog dosing table above for species-specific guidance. Used for dermatomyositis, vasculitis, and microcirculatory disorders. GI upset common (give with food). Do not crush ER tablets. Generally well tolerated.
Why a species-specific page? Pentoxifylline pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.