Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Pentoxifylline (Respiratory) is dosed at 10–25 mg/kg PO q8-12h in dogs, per Koch S, Torres S, Plumb D. Small Animal Dermatology Drug Handbook. Wiley-Blackwell; 2012. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1030 (2026-08-01). — Plumb's 10th ed (held) printed p.1002, Pentoxifylline monograph spanning p.1002-1003; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207; Muller & Kirk's Small Animal Dermatology — ISBN 9781416000280, https://openlibrary.org/isbn/9781416000280. Pentoxifylline (Respiratory) is used in dogs for Pulmonary fibrosis / vasculitis adjunct. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Pentoxifylline (Respiratory) in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Trental
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 10–25 mg/kg | q8-12h | Long-term; months to assess efficacy | Pulmonary fibrosis / vasculitis adjunct | Moderate | Koch S, Torres S, Plumb D. Small Animal Dermatology Drug Handbook. Wiley-Blackwell; 2012. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1030 (2026-08-01). — Plumb's 10th ed (held) printed p.1002, Pentoxifylline monograph spanning p.1002-1003; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207; Muller & Kirk's Small Animal Dermatology — ISBN 9781416000280, https://openlibrary.org/isbn/9781416000280 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
The sources disagree for this combination. The ranges below do not overlap on a comparable route. This is not an error in one of them — published veterinary references differ, and reconciling them for a particular patient is a clinical judgement.
| Dose (mg/animal) | Route | Source | As printed |
|---|---|---|---|
| 400 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.649 | • Other uses: 10-15 mg/kg q8 PO or 400 mg/dog for most animals. |
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 15 | — | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.328 | 15 mg/kg q8-12h |
| 10 | PO |
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Non-selective phosphodiesterase inhibitor that improves red blood cell deformability, reduces blood viscosity, and inhibits TNF-alpha and neutrophil activation in pulmonary vasculature.
GI upset at initiation. Used for pulmonary fibrosis and chronic bronchitis adjunct therapy. Anti-inflammatory effects complement bronchodilators.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Pentoxifylline (Respiratory) dose range in dogs, with cited source references: PO 10–25 mg/kg q8-12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Pentoxifylline (Respiratory) in dogs: PO.
Cited course lengths for Pentoxifylline (Respiratory) in dogs include: Long-term; months to assess efficacy. Duration depends on the indication — match it to the specific dose rule in the table above.
Pentoxifylline (Respiratory) is indicated in dogs for: Pulmonary fibrosis / vasculitis adjunct.
These are general warnings for Pentoxifylline (Respiratory) across species; consult the dog dosing table above for species-specific guidance. GI upset at initiation. Used for pulmonary fibrosis and chronic bronchitis adjunct therapy. Anti-inflammatory effects complement bronchodilators.
Why a species-specific page? Pentoxifylline (Respiratory) pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.
| Papich Saunders Handbook of Veterinary Drugs, 4th edp.649 |
| • Dermatologic use: 10 mg/kg q12h PO, up to 15 mg/kg q8h PO. |
| 15 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.649 | • Dermatologic use: 10 mg/kg q12h PO, up to 15 mg/kg q8h PO. |
| 25 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.649 | • Familial canine dermatomyositis: 25 mg/kg q12h PO. |
| 10–15 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.649 | • Other uses: 10-15 mg/kg q8 PO or 400 mg/dog for most animals. |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.